Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors,Small

当前位置： X-MOL 学术 › Small › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors
Small ( IF 13.0 ) Pub Date : 2021-04-22 , DOI: 10.1002/smll.202100398
Hui Bian ₁ , Dandan Ma ₁ , Xinfu Zhang ₁ , Kai Xin ₂ , Youjun Yang ₂ , Xiaojun Peng ₁ , Yi Xiao ₁

Affiliation

Small molecular dye that simultaneously exerts dual PDT/PTT effects as well as florescence imaging triggered by a single NIR-II light has never been reported to date. Apart from the huge challenge in pushing absorption profile into NIR-II region, fine-tuning dyes’ excited state via rational structure design to meet all three functions, especially oxygen photosensitization, remains the most prominent throttle. Herein, five novel NIR-II dyes (BHs) are productively developed by strategically conjugating dyad innovative xanthonium with sequentially extended polymethine bridges, enabling intense absorption from 890 to 1206 nm, significantly 400 nm longer than conventional cyanine dyes with same polymethines. More importantly, owning to high resonance and favorable excited state energy population induced by greater rigidity via ring-fused amino, BH 1024 exhibits best singlet oxygen generation capability, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Furthermore, BH 1024 is encapsulated into folate-functionalized polymer, which demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. As far as it is known, this is the first time small molecular dyes for NIR-II PDT or NIR-II PDT/PTT are explored and designed.

中文翻译：

针对1064 nm激光触发的协同作用的PDT和PTT的新型黄嘌呤多甲胺染料的定制工程。

迄今为止，从未报道过同时发挥双重PDT / PTT效果以及由单个NIR-II光触发的荧光成像的小分子染料。除了将吸收曲线推向NIR-II区域的巨大挑战之外，通过合理的结构设计来微调染料的激发态以满足所有三个功能，尤其是氧气的光敏性，仍然是最重要的节流阀。在此，通过策略性地将双色创新黄嘌呤与顺序延伸的聚次甲基桥键合，从而生产出五种新型的NIR-II染料（BH），它们能够从890到1206 nm进行强吸收，比具有相同聚次甲基的传统花青染料长400 nm。更重要的是，由于通过环稠合的氨基具有更高的刚性，因此具有高共振和有利的激发态能量，BH 1024具有最佳的单线态氧产生能力，适度的光热加热以及在1064 nm激光照射下可观的荧光。此外，BH 1024封装在叶酸官能化的聚合物中，在体内和体外显示出协同的PDT / PTT效应，最终在NIR-II荧光引导下实现了实体瘤消除。据了解，这是首次探索和设计用于NIR-II PDT或NIR-II PDT / PTT的小分子染料。最终在NIR-II荧光引导下实现了实体瘤消除。据了解，这是首次探索和设计用于NIR-II PDT或NIR-II PDT / PTT的小分子染料。最终在NIR-II荧光引导下实现了实体瘤消除。据了解，这是首次探索和设计用于NIR-II PDT或NIR-II PDT / PTT的小分子染料。

更新日期：2021-05-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南