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Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-05-03 , DOI: 10.1021/acs.chemrev.0c01291 Qiao Song 1 , Zihe Cheng 1 , Maria Kariuki 1 , Stephen C L Hall 1 , Sophie K Hill 1 , Julia Y Rho 1 , Sébastien Perrier 1, 2, 3
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-05-03 , DOI: 10.1021/acs.chemrev.0c01291 Qiao Song 1 , Zihe Cheng 1 , Maria Kariuki 1 , Stephen C L Hall 1 , Sophie K Hill 1 , Julia Y Rho 1 , Sébastien Perrier 1, 2, 3
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This Review focuses on the establishment and development of self-assemblies governed by the supramolecular interactions between cyclic peptides. The Review first describes the type of cyclic peptides able to assemble into tubular structures to form supramolecular cyclic peptide nanotubes. A range of cyclic peptides have been identified to have such properties, including α-peptides, β-peptides, α,γ-peptides, and peptides based on δ- and ε-amino acids. The Review covers the design and functionalization of these cyclic peptides and expands to a recent advance in the design and application of these materials through their conjugation to polymer chains to generate cyclic peptide–polymer conjugates nanostructures. The Review, then, concentrates on the challenges in characterizing these systems and presents an overview of the various analytical and characterization techniques used to date. This overview concludes with a critical survey of the various applications of the nanomaterials obtained from supramolecular cyclic peptide nanotubes, with a focus on biological and medical applications, ranging from ion channels and membrane insertion to antibacterial materials, anticancer drug delivery, gene delivery, and antiviral applications.
中文翻译：
环肽的分子自组装和超分子化学
本综述重点关注环肽之间超分子相互作用控制的自组装体的建立和发展。该评论首先描述了能够组装成管状结构以形成超分子环肽纳米管的环肽类型。一系列环肽已被鉴定具有此类特性，包括α-肽、β-肽、α,γ-肽以及基于δ-和ε-氨基酸的肽。该综述涵盖了这些环肽的设计和功能化，并扩展到这些材料的设计和应用的最新进展，通过它们与聚合物链的缀合生成环肽-聚合物缀合物纳米结构。然后，该评论集中讨论表征这些系统的挑战，并概述迄今为止使用的各种分析和表征技术。本概述最后对从超分子环肽纳米管获得的纳米材料的各种应用进行了批判性调查，重点是生物和医学应用，从离子通道和膜插入到抗菌材料、抗癌药物输送、基因输送和抗病毒应用程序。
更新日期：2021-05-03
中文翻译：
环肽的分子自组装和超分子化学
本综述重点关注环肽之间超分子相互作用控制的自组装体的建立和发展。该评论首先描述了能够组装成管状结构以形成超分子环肽纳米管的环肽类型。一系列环肽已被鉴定具有此类特性，包括α-肽、β-肽、α,γ-肽以及基于δ-和ε-氨基酸的肽。该综述涵盖了这些环肽的设计和功能化，并扩展到这些材料的设计和应用的最新进展，通过它们与聚合物链的缀合生成环肽-聚合物缀合物纳米结构。然后，该评论集中讨论表征这些系统的挑战，并概述迄今为止使用的各种分析和表征技术。本概述最后对从超分子环肽纳米管获得的纳米材料的各种应用进行了批判性调查，重点是生物和医学应用，从离子通道和膜插入到抗菌材料、抗癌药物输送、基因输送和抗病毒应用程序。
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