Microchimica Acta ( IF 5.3 ) Pub Date : 2021-04-29 , DOI: 10.1007/s00604-021-04832-y Ruijuan Zheng 1 , Yingchen Yang 1 , Chang Yang 1 , Yan Xia 1, 2
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A core-shell material (UiO@TapbTp) has been developed as an adsorbent and matrix to detect nonsteroidal anti-inflammatory drugs (NSAIDS) by matrix laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in complex samples. The hybrid material is prepared by growing covalent organic framework (COF, TapbTp) layers in situ on an amino-modified metal-organic framework (MOF, UiO-66-NH2). The combination of the MOF and COF overcomes their individual shortcomings and integrates both of their advantages. Compared with the bare COF and MOF, the core-shell composite exhibits improved enrichment ability and matrix performance. With the help of pre-enrichment under optimized conditions, the limits of detection (LODs) for ketoprofen, naproxen, and aspirin are reduced by nearly 1000 times, with values of 0.001 mg L−1, 0.010 mg L−1, and 0.001 mg L−1, respectively, and the relative standard deviations (RSDs) are all below 12.35%. The good recoveries (84.8–118%) in (spiked) saliva and environmental water sample further verify the applicability of the method in complex samples.
Graphical abstract
中文翻译：
核壳 MOF@COFs 用作吸附剂和基质，用于通过 MALDI-TOF MS 检测非甾体抗炎药
已开发出一种核壳材料 (UiO@TapbTp) 作为吸附剂和基质，通过基质激光解吸/电离飞行时间质谱 (MALDI-TOF MS) 检测复杂样品中的非甾体抗炎药 (NSAIDS) . 该杂化材料是通过在氨基修饰的金属有机骨架（MOF、UiO-66-NH 2）上原位生长共价有机骨架（COF、TapbTp）层来制备的）。MOF 和 COF 的结合克服了它们各自的缺点并整合了它们的优点。与裸 COF 和 MOF 相比，核壳复合材料具有更高的富集能力和基体性能。借助优化条件下的预富集，酮洛芬、萘普生和阿司匹林的检测限 (LOD) 降低了近 1000 倍，分别为 0.001 mg L -1、0.010 mg L -1和 0.001 mg L -1分别和相对标准偏差 (RSD) 均低于 12.35%。（加标）唾液和环境水样中的良好回收率 (84.8–118%) 进一步验证了该方法在复杂样品中的适用性。
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