Massive bleeding and infectious complication remain the leading cause of worldwide trauma deaths. To tackle this issue, a platelet-inspired degradable antibacterial hydrogel (Gel/PP-TA-Ag) is synthesized based on gelatin methacrylate (GelMA), tannic acid (TA), polyphosphate (PolyP) and gallic acid functionalized silver nanoparticles (Ag NPs) via a facile photopolymerization process. Accompanied by the degradation of the hydrogel, the released PolyP can activate the coagulation pathway, resulting in a better hemostatic effect than commercial gauze in the mice-bleeding model. Simultaneously, benefiting from hyperthermia originated from Ag NPs and photothermal accelerated release of TA and Ag⁺, 97.57% of methicillin-resistant Staphylococcus aureus (MRSA) and 95.99% of E. coli are eliminated in vitro. Moreover, in vivo experiments reveal that 91.76% of MRSA in wounds is removed, and the wound healing is effectively improved with more angiogenesis and collagen deposition. The level of inflammation in the wounds is also significantly reduced. As a result, Gel/PP-TA-Ag hydrogel possesses great potential in achieving satisfactory efficacy in infected wound healing.

大量出血和感染性并发症仍然是全世界创伤死亡的主要原因。为解决此问题，基于甲基丙烯酸明胶（GelMA），单宁酸（TA），多磷酸盐（PolyP）和没食子酸官能化的银纳米颗粒（Ag NPs）合成了血小板启发的可降解抗菌水凝胶（Gel / PP-TA-Ag）。 ）通过简便的光聚合过程进行。伴随着水凝胶的降解，释放的PolyP可以激活凝血途径，在小鼠出血模型中比商业用纱布具有更好的止血效果。同时，得益于Ag NPs引起的热疗和TA和Ag ^+的光热加速释放，耐甲氧西林金黄色葡萄球菌（MRSA）占97.57％）和95.99％的大肠杆菌在体外被清除。此外，体内实验显示，伤口中的MRSA被去除了91.76％，并且随着更多的血管生成和胶原蛋白沉积，伤口愈合得到了有效改善。伤口中的炎症水平也大大降低。结果，Gel / PP-TA-Ag水凝胶具有在感染伤口愈合中获得令人满意的功效的巨大潜力。