Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction,Nanoscale

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Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Nanoscale ( IF 5.8 ) Pub Date : 2021-4-7 , DOI: 10.1039/d1nr00038a
Jiyan Qiao _{1,

2,

3,

4,

5} , Rui Chen _{1,

2,

3,

4} , Mengjie Wang _{1,

2,

3,

4} , Ru Bai _{1,

2,

3,

4} , Xuejing Cui _{1,

2,

3,

4} , Ying Liu _{1,

2,

3,

4} , Chongming Wu _{3,

4,

6,

7} , Chunying Chen _{1,

2,

3,

4,

5}

Affiliation

The widespread occurrence of microplastics (MPLs) and nanoplastics (NPLs), collectively abbreviated as M/NPLs, has markedly affected the ecosystem and has become a global threat to human health. Multiple investigations have shown that the chronic ingestion of M/NPLs negatively affects gut barrier function but the mechanism remains unclear. Herein, this research has investigated the toxic effects of pristine polystyrene (PS) M/NPLs, negatively charged carboxylated polystyrene M/NPLs (PS-COOH) and positively charged aminated polystyrene M/NPLs (PS-NH₂) of two sizes (70 nm and 5 μm in diameter) in mice. Gavage of these PS M/NPLs for 28 days caused obvious injuries to the gut tract, leading to the decreased expression of tight junction proteins. The toxicity of the M/NPLs was ranked as PS-NH₂ > PS-COOH > pristine PS. Oral administration of these M/NPLs resulted in marked gut microbiota dysbiosis. The M/NPLs-enriched genera generally contained opportunistic pathogens which are accompanied by a deteriorated intestinal barrier function, while most M/NPLs-decreased bacteria were beneficial microbes with known tight junction-promoting functions, implicating an important indirect toxic effect of gut microbiota dysbiosis in M/NPLs-induced gut barrier dysfunction. In conclusion, this research highlights the importance of gut microbiota in the toxicity of M/NPLs exposure on gut barrier function, providing novel insights into the adverse effects of M/NPLs exposure on human health.

中文翻译：

肠道菌群的摄动在微量/纳米塑料诱导的肠道屏障功能障碍中起重要作用

统称为M / NPL的微塑料（MPL）和纳米塑料（NPL）的广泛出现已显着影响了生态系统，并已成为对人类健康的全球威胁。多项研究表明，长期摄入M / NPL对肠道屏障功能有负面影响，但机制尚不清楚。本文中，本研究调查了两种尺寸（70）的原始聚苯乙烯（PS）M / NPL，带负电荷的羧基化聚苯乙烯M / NPL（PS-COOH）和带正电荷的胺化聚苯乙烯M / NPL（PS-NH ₂）的毒性作用。nm和直径5μm）。这些PS M / NPL的管饲持续了28天，对肠道造成了明显的伤害，导致紧密连接蛋白的表达下降。M / NPL的毒性被列为PS-NH ₂> PS-COOH>原始PS。口服这些M / NPL会导致明显的肠道菌群失调。富含M / NPLs的属通常包含机会病原体，并伴有肠道屏障功能的降低，而大多数M / NPLs降低的细菌是具有已知紧密连接促进功能的有益微生物，这暗示了肠道微生物群失调的重要间接毒性作用。 M / NPLs引起的肠道屏障功能障碍。总之，这项研究强调了肠道菌群在M / NPLs暴露对肠道屏障功能的毒性中的重要性，为M / NPLs暴露对人体健康的不利影响提供了新的见解。

更新日期：2021-04-27

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