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UV-Assisted Deposition of Antibacterial Ag–Tannic Acid Nanocomposite Coating
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-04-26 , DOI: 10.1021/acsami.1c03566
Xiaodong He 1 , Kasi Gopinath 1 , Gnanasekar Sathishkumar 1 , Lingli Guo 1 , Kai Zhang 1, 2 , Zhisong Lu 1, 2 , Changming Li 1 , En-Tang Kang 1, 3 , Liqun Xu 1, 2
Affiliation  

The marked increase in bacterial colonization of medical devices and multiple drug resistance to traditional antibiotics underline the pressing need for developing novel antibacterial surface coatings. In the present investigation, natural polyphenol tannic acid (TA)-capped silver nanoparticles (TA–Ag NPs) were synthesized via an environmentally friendly and sustainable one-step redox reaction under UV irradiation with a simultaneous and uniform deposition on polydimethylsiloxane (PDMS) and other substrate surfaces. In the synthesis process, the dihydroxyphenyl and trihydroxyphenyl groups of TA actively participate in Ag+ reduction, forming co-ordination linkages with Ag NPs and bestowing the deposition on the PDMS surface. The physico-chemical features of TA–Ag NPs were characterized in detail. Microscopic examination, surface elemental analysis, and wettability measurements clearly reveal the decoration of TA–Ag NPs on the substrate surfaces. The modified PDMS surfaces can kill the adhered bacteria or resist the bacterial adhesion, and no live bacteria can be found on their surfaces. Most importantly, the modified PDMS surfaces exhibit predominant antibacterial effects both in vitro in the catheter bridge model and in vivo in a rat subcutaneous infection model. On the other hand, the functionalized surfaces exhibit only a negligible level of cytotoxicity against L929 mouse fibroblasts with no side effects on the major organs of Sprague–Dawley rats after implantation, indicating their biocompatibility for potential biomedical applications.

中文翻译:

抗菌银单宁酸纳米复合涂层的紫外辅助沉积

医疗器械细菌定植的显着增加以及对传统抗生素的多重耐药性凸显了开发新型抗菌表面涂层的迫切需要。在本研究中,天然多酚单宁酸 (TA) 封端的银纳米粒子 (TA-Ag NPs) 在紫外线照射下通过环境友好且可持续的一步氧化还原反应合成,同时均匀沉积在聚二甲基硅氧烷 (PDMS) 和其他基材表面。在合成过程中,TA的二羟基苯基和三羟基苯基主动参与Ag +还原,与 Ag NPs 形成配位键,并在 PDMS 表面沉积。TA-Ag NPs 的物理化学特征被详细表征。显微镜检查、表面元素分析和润湿性测量清楚地揭示了 TA-Ag NPs 在基材表面上的装饰。改性的PDMS表面可以杀死粘附的细菌或抵抗细菌的粘附,并且在其表面上找不到活细菌。最重要的是,改性的 PDMS 表面在导管桥模型的体外和大鼠皮下感染模型中均表现出显着的抗菌作用。另一方面,
更新日期:2021-05-05
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