Practical allylation with unactivated allylic alcohols under mild conditions,Organic Chemistry Frontiers

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Practical allylation with unactivated allylic alcohols under mild conditions
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-4-19 , DOI: 10.1039/d1qo00490e
Shuangshuang Li _{1,

2,

3,

4} , Ju Qiu _{1,

2,

3,

4} , Bowen Li _{1,

2,

3,

4} , Zuolian Sun _{1,

2,

3,

4} , Peizhong Xie _{1,

2,

3,

4} , Teck-Peng Loh _{1,

2,

3,

4,

5}

Affiliation

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcohols. EtOH solvent with a H₂O additive was identified as powerful medium to accelerate proton transfer. This catalytic system and environmentally benign medium enabled a variety of soft carbonic nucleophiles and allylic alcohols to react smoothly at room temperature with water as the only byproduct. A wide spectrum of allylic compounds bearing a variety of functional groups can be obtained with high to excellent yields.

中文翻译：

在温和条件下与未活化的烯丙醇实际进行烯丙基化

开发了一种实用的钯/钙催化体系，用于与未活化的烯丙醇进行脱水烯丙基化。具有H ₂ O添加剂的EtOH溶剂被认为是加速质子转移的有效介质。这种催化系统和对环境无害的介质使各种软碳亲核试剂和烯丙醇在室温下与水作为唯一的副产物能够平稳反应。可以高产率至优异产率获得带有各种官能团的多种烯丙基化合物。

更新日期：2021-04-27

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