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Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-04-23 , DOI: 10.1021/acssuschemeng.1c01064
Beibei Lu 1, 2 , Mingjie Yi 1, 2 , Shunyou Hu 1, 2 , Dong Wu 1, 2 , Zhenye Zhu 1, 2 , Chengyu Wu 1, 2 , Zhenyuan Wang 3 , Yuanbin Li 3 , Jiaheng Zhang 1, 2
Affiliation  

Tumor is one of the most serious forms of abnormal growth that endangers human health today; its morbidity and mortality are both increasing every year. Most of the antitumor drugs used currently cannot be absorbed well by the human body because of their poor solubility and low bioavailability. Therefore, the prevention and treatment of tumors are still of high significance. These challenges can be addressed by the use of ionic liquids (ILs). Half of the antitumor drugs currently in the market are salts linked together by ILs. Compared to the solid form of the drug, the salt that is liquid at room temperature or body temperature shows good solubility, absorption, and stability. Therefore, in this study, we combined taurine with antitumor activity and alkaloids with biological activity (l-(−)-carnitine or betaine) to produce IL salts possessing the merits of both these components to develop an efficient and cost-effective drug delivery system for tumor treatment. Taurine-based ILs can deliver proteins such as insulin or dextran, which are promising drug delivery carriers. In vitro experiments showed that the taurine-based IL exhibited good biocompatibility, non-toxicity, and antitumor activity. Compared to the blank group, the proliferation inhibition rate of human colon adenocarcinoma cells (Caco-2) treated with different concentrations of taurine-based ILs increased significantly. The inhibitory effect of the taurine-based IL on Caco-2 cell proliferation became more pronounced with an increase in its concentration and the treatment time. Moreover, the results suggested that the combination of taurine-based ILs and chemotherapy drugs can improve the efficacy of chemotherapy drugs and reduce their adverse reactions. Interestingly, taurine-based ILs can inhibit the growth of tumor cells by inducing apoptosis in tumor cells after 4 h. This demonstrates the immense potential of taurine-based ILs in inhibiting the growth of tumor cells.

中文翻译:

基于牛磺酸的离子液体,用于透皮蛋白递送和增强的抗癌活性

肿瘤是当今危害人类健康的最严重的异常增长形式之一。它的发病率和死亡率每年都在增加。当前使用的大多数抗肿瘤药物由于其不良的溶解性和低的生物利用度而不能被人体很好地吸收。因此,肿瘤的预防和治疗仍具有重要意义。这些挑战可以通过使用离子液体(IL)来解决。目前市场上一半的抗肿瘤药物是通过IL连接在一起的盐。与药物的固体形式相比,在室温或体温下呈液态的盐显示出良好的溶解性,吸收性和稳定性。因此,在本研究中,我们具有抗肿瘤活性和生物碱具有生物活性(联合牛磺酸-(-)-肉碱或甜菜碱)来生产具有这两种成分优点的IL盐,从而开发出一种高效且具有成本效益的药物递送系统来治疗肿瘤。基于牛磺酸的IL可以递送蛋白质,例如胰岛素或右旋糖酐,它们是有前途的药物递送载体。体外实验表明,基于牛磺酸的IL表现出良好的生物相容性,无毒和抗肿瘤活性。与空白组相比,用不同浓度的牛磺酸基ILs处理的人结肠腺癌细胞(Caco-2)的增殖抑制率显着提高。随着浓度和处理时间的增加,基于牛磺酸的IL对Caco-2细胞增殖的抑制作用变得更加明显。而且,结果表明,牛磺酸基ILs与化疗药物联合使用可提高化疗药物的疗效并减少其不良反应。有趣的是,基于牛磺酸的ILs可以在4 h后通过诱导肿瘤细胞凋亡来抑制肿瘤细胞的生长。这证明了基于牛磺酸的IL在抑制肿瘤细胞生长方面的巨大潜力。
更新日期:2021-05-03
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