Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells,Molecular Nutrition & Food Research

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Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-04-23 , DOI: 10.1002/mnfr.202000799
Hee-Weon Lee ₁ , Min Ji Gu ₁ , Jee-Young Lee ₂ , Seungju Lee ₂ , Yoonsook Kim ₁ , Sang Keun Ha _{1,

3}

Affiliation

Advanced glycation end products (AGEs) and receptor of advanced glycation end products (RAGE) mediate renal function during diabetic and non-diabetic nephropathy development. Methylglyoxal-lysine dimer (MOLD), a typical toxic advanced glycation end product (TAGE), contributes to inflammatory responses during renal diseases. This study determines the effect of MOLD on inflammatory responses in mouse mesangial cells.

中文翻译：

甲基乙二醛-赖氨酸二聚体，一种高级糖化终产物，通过与系膜细胞中的 RAGE 相互作用诱导炎症

晚期糖基化终末产物 (AGEs) 和晚期糖基化终末产物 (RAGE) 受体在糖尿病和非糖尿病肾病发展过程中介导肾功能。甲基乙二醛-赖氨酸二聚体 (MOLD) 是一种典型的有毒晚期糖基化终产物 (TAGE)，在肾脏疾病期间会导致炎症反应。本研究确定了 MOLD 对小鼠系膜细胞炎症反应的影响。

更新日期：2021-07-02

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