Substrate-Controlled Cu(OAc)2-Catalyzed Stereoselective Semi-Reduction of Alkynes with MeOH as the Hydrogen Source,ACS Omega

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Substrate-Controlled Cu(OAc)2-Catalyzed Stereoselective Semi-Reduction of Alkynes with MeOH as the Hydrogen Source
ACS Omega ( IF 3.7 ) Pub Date : 2021-04-22 , DOI: 10.1021/acsomega.1c01083
Jiuzhong Huang ₁ , Xiaoning Li ₂ , Huiling Wen ₁ , Lu Ouyang ₁ , Nianhua Luo ₁ , Jianhua Liao ₁ , Renshi Luo ₁

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A substrate-controlled stereoselective semi-reduction of alkynes with MeOH as the hydrogen source has been developed, and readily available Cu(OAc)₂ (copper acetate) is utilized as an optimal catalyst. The detailed investigation of the mechanism revealed distinct catalytic processes for the (Z)- and (E)-alkenes, respectively. As a result, a diversity of alkynes (including terminal, internal alkynes etc.) were compatible under the mild reaction conditions. Furthermore, the high proportion of deuterium in Z-alkenes (up to 96%) was obtained using d₄-methanol as a solvent.

中文翻译：

底物控制的Cu（OAc）_2-以MeOH为氢源的炔烃立体选择性半还原

已开发出以MeOH为氢源的炔烃可控制的底物控制的立体选择性半还原反应，现将易得的Cu（OAc）₂（醋酸铜）用作最佳催化剂。对该机理的详细研究揭示了分别对（Z）-和（E）-烯烃的不同催化过程。结果，在温和的反应条件下，各种炔烃（包括末端，内部炔烃等）是相容的。此外，使用d _4-甲醇作为溶剂，可以获得Z-烯烃中氘的比例很高（最高96％）。

更新日期：2021-05-04

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