Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C–H Olefination,The Journal of Organic Chemistry

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Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C–H Olefination
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-04-22 , DOI: 10.1021/acs.joc.1c00042
Wen-Liang Jia ₁ , Sabela Vega Ces ₁ , M Ángeles Fernández-Ibáñez ₁

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Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by late-stage C–H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C–H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.

中文翻译：

后期CHH渗碳处理与Yaequinolone相关的天然产物的总合成量不同

10 yaequinolone相关的天然产物的不同的总的合成是通过3,4-二加氧的4-芳基-5-羟基喹啉2（1 H）-的1 ，C的核心结构的后期C–H烯化反应首次实现的。这一系列的天然产品。建立了一种可靠的构建核心结构的合成方法，并在温和的反应条件下，存在Pd / S，O-的条件下以合成有用的收率和高水平的位点选择性进行了C–H烯化反应。配体催化剂。

更新日期：2021-05-07

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