Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties,European Journal of Organic Chemistry

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Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-04-22 , DOI: 10.1002/ejoc.202100362
Frédéric Lassagne ₁ , Joshua M. Sims _{1,

2} , William Erb ₁ , Olivier Mongin ₁ , Nicolas Richy ₁ , Nour El Osmani ₃ , Ziad Fajloun _{3,

4} , Laurent Picot ₅ , Valérie Thiéry ₅ , Thomas Robert _{6,

7} , Stéphane Bach _{6,

7,

8} , Vincent Dorcet ₁ , Thierry Roisnel ₁ , Florence Mongin ₁

Affiliation

Oxazolo[5,4-f]quinoxalines, thiazolo[5,4-f]quinoxalines and pyrazino[b,e]isatins were all obtained from 5-iodo-6-aminoquinoxalines. While the first two families were synthesized by nitrogen functionalization and subsequent copper-catalyzed cyclization, the latter was obtained by Sonogashira coupling, alkyne hydration, and oxidative cyclization. Most of the synthesized polycycles were evaluated in biological tests.

中文翻译：

噻唑并[5,4-f]喹喔啉，恶唑并[5,4-f]喹喔啉和吡嗪并[b，e] isatins：由6-氨基喹喔啉合成及性质

恶唑啉[5,4- f ]喹喔啉，噻唑并[5,4- f ]喹喔啉和吡嗪并[ b，e ] isatins都是从5-碘-6-氨基喹喔啉中获得的。前两个族是通过氮官能化和随后的铜催化环化合成的，而后者是通过Sonogashira偶联，炔烃水合和氧化环化获得的。大多数合成的多环化合物在生物学测试中进行了评估。

更新日期：2021-05-19

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