Chemical Engineering Journal ( IF 13.3 ) Pub Date : 2021-04-22 , DOI: 10.1016/j.cej.2021.130005
Xiaodong He , Gnanasekar Sathishkumar , Kasi Gopinath , Kai Zhang , Zhisong Lu , Changming Li , En-Tang Kang , Liqun Xu
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Severe medical device-associated infections caused by pathogenic bacteria have become an immediate threat to global public health, mainly because of the development of multiple drug resistance (MDR). Relevant design of functionalized biomaterials are thus essential to remit or mitigate the medical device-associated infections. In the present work, we developed a strategy of combining antifouling and photothermal therapy (PTT) in a single platform for antibacterial applications. The polydimethylsiloxane (PDMS) surface was modified with poly(ethylene glycol) (PEG) and tannic acid-reduced gold nanoparticles (Au@TA NPs) for better photothermal and antifouling performance. PEG facilitates the rapid self-assembly of Au@TA NPs on the surface to form a stable Au@TA NPs/PEG (TA-PEG-Au) layer. The functionalized surface with antifouling and antibacterial properties arise from the inherent fouling resistance of PEG and photothermal conversion of Au NPs. The TA-PEG-Au coating exhibits remarkable antifouling performance to bacterial adhesion and excellent antibacterial property under near-infrared (NIR) irradiation both in vitro and in vivo. The antibacterial TA-PEG-Au coatings also show low cytotoxicity. The present work provides an efficient strategy for the design of high-performance antifouling and antibacterial materials to fight against medical device-associated infections.
中文翻译:
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生物金Au NPs / PEG基通用涂层的一步自组装,用于细菌病原体的防污和光热杀灭
致病细菌引起的与医疗设备相关的严重感染已成为对全球公共健康的直接威胁,这主要是由于多重耐药性(MDR)的发展。因此,功能化生物材料的相关设计对于缓解或减轻与医疗器械相关的感染至关重要。在当前的工作中,我们开发了在单个平台上将抗菌防污和光热疗法(PTT)相结合的策略。聚二甲基硅氧烷(PDMS)表面用聚乙二醇(PEG)和单宁酸还原的金纳米颗粒(Au @ TA NPs)改性,具有更好的光热和防污性能。PEG有助于表面上Au @ TA NP的快速自组装,从而形成稳定的Au @ TA NPs / PEG(TA-PEG-Au)层。具有防污和抗菌特性的功能化表面源自PEG固有的防污性和Au NPs的光热转化。TA-PEG-Au涂层对细菌的附着力表现出卓越的防污性能,并且在近红外(NIR)辐射下均具有出色的抗菌性能体外和体内。抗菌TA-PEG-Au涂层也显示出低细胞毒性。目前的工作为设计高性能的防污和抗菌材料提供了有效的策略,以抗击与医疗器械相关的感染。