A Nature inspired strategy to oxidized aromatic bisabolanes has been envision from naturally occurring 2-methyl-6-(4′-methylphenyl)-3-hepten-2-ol (2a). The key methodology utilized in this synthesis is the allylic oxidative rearrangement following a [3,3]-sigmatropic rearrangement (Dauben oxidation) of tertiary allylic alcohol of natural product 2a. The enantioselectivity of 2a has been introduced via a Rh(I)-(S)-BINAP catalyzed p-tolylboronic acid addition onto E-ethylcrotonate. Thus, the total syntheses of (–)-ar-turmerone (1a), (-)-dihydro-ar-turmerone (1b) and (-)-ar-himachalene (3) has been achieved only in 6–7 steps.

从天然存在的 2-methyl-6-(4'-methylphenyl)-3-hepten-2-ol ( 2a ) 中设想了一种受自然启发的氧化芳香族红没药醇的策略。在此合成中使用的关键方法是烯丙基氧化重排后 [3,3]-sigmatropic 重排（道本氧化）的天然产物2a叔烯丙醇。2a的对映选择性是通过 Rh(I)-(S)-BINAP 催化的对甲苯基硼酸加成到E-乙基巴豆酸酯上来引入的。因此，(-)- ar -turmerone ( 1a ), (-)- dihydro - ar -turmerone ( 1b ) 和 (-)- ar-himahalene ( 3 ) 仅在 6-7 个步骤中实现。