当前位置：
X-MOL 学术
›
Acta Biomater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
PEG-based thermosensitive and biodegradable hydrogels
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2021-04-20 , DOI: 10.1016/j.actbio.2021.04.009 Jiayue Shi 1 , Lin Yu 2 , Jiandong Ding 2
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2021-04-20 , DOI: 10.1016/j.actbio.2021.04.009 Jiayue Shi 1 , Lin Yu 2 , Jiandong Ding 2
Affiliation
|
Injectable thermosensitive hydrogels are free-flowing polymer solutions at low or room temperature, making them easy to encapsulate the therapeutic payload or cells via simply mixing. Upon injection into the body, forming hydrogels triggered by body temperature can act as drug-releasing reservoirs or cell-growing scaffolds. Finally, the hydrogels are eliminated from the administration sites after they accomplish their missions as depots or scaffolds. This review outlines the recent progress of poly(ethylene glycol) (PEG)-based biodegradable thermosensitive hydrogels, especially those composed of PEG-polyester copolymers, PEG-polypeptide copolymers and poly(organophosphazene)s. The material design, performance regulation, thermogelation and degradation mechanisms, and corresponding applications in the biomedical field are summarized and discussed. A perspective on the future thermosensitive hydrogels is also highlighted. Thermosensitive hydrogels undergoing reversible sol-to-gel phase transitions in response to temperature variations are a class of promising biomaterials that can serve as minimally invasive injectable systems for various biomedical applications. Hydrophilic PEG is a main component in the design and fabrication of thermoresponsive hydrogels due to its excellent biocompatibility. By incorporating hydrophobic segments, such as polyesters and polypeptides, into PEG-based systems, biodegradable and thermosensitive hydrogels with adjustable properties and have been developed and have recently become a research hotspot of biomaterials. The summary and discussion on molecular design, performance regulation, thermogelation and degradation mechanisms, and biomedical applications of PEG-based thermosensitive hydrogels may offer a demonstration of blueprint for designing new thermogelling systems and expanding their application scope.
中文翻译：
基于 PEG 的热敏和可生物降解水凝胶
可注射的热敏水凝胶是在低温或室温下自由流动的聚合物溶液，使其通过简单的混合即可轻松封装治疗有效负载或细胞。注射到体内后，由体温触发形成的水凝胶可以充当药物释放库或细胞生长支架。最后，水凝胶在完成其作为储存库或支架的使命后，从给药部位被清除。本文概述了基于聚乙二醇（PEG）的可生物降解热敏水凝胶的最新进展，特别是由PEG-聚酯共聚物、PEG-多肽共聚物和聚（有机磷腈）组成的水凝胶。对材料设计、性能调控、热凝胶和降解机制以及在生物医学领域的应用进行了总结和讨论。还强调了对未来热敏水凝胶的展望。热敏水凝胶响应温度变化而经历可逆的溶胶到凝胶相变，是一类有前途的生物材料，可以作为各种生物医学应用的微创注射系统。亲水性 PEG 因其优异的生物相容性而成为热响应水凝胶设计和制造的主要成分。通过将聚酯和多肽等疏水链段纳入基于PEG的体系中，开发出具有可调节性能的可生物降解的热敏水凝胶，并成为近年来生物材料的研究热点。 对基于PEG的热敏水凝胶的分子设计、性能调节、热凝胶和降解机制以及生物医学应用的总结和讨论可以为设计新的热凝胶系统和扩大其应用范围提供示范蓝图。
更新日期：2021-04-20
中文翻译：
基于 PEG 的热敏和可生物降解水凝胶
可注射的热敏水凝胶是在低温或室温下自由流动的聚合物溶液，使其通过简单的混合即可轻松封装治疗有效负载或细胞。注射到体内后，由体温触发形成的水凝胶可以充当药物释放库或细胞生长支架。最后，水凝胶在完成其作为储存库或支架的使命后，从给药部位被清除。本文概述了基于聚乙二醇（PEG）的可生物降解热敏水凝胶的最新进展，特别是由PEG-聚酯共聚物、PEG-多肽共聚物和聚（有机磷腈）组成的水凝胶。对材料设计、性能调控、热凝胶和降解机制以及在生物医学领域的应用进行了总结和讨论。还强调了对未来热敏水凝胶的展望。热敏水凝胶响应温度变化而经历可逆的溶胶到凝胶相变，是一类有前途的生物材料，可以作为各种生物医学应用的微创注射系统。亲水性 PEG 因其优异的生物相容性而成为热响应水凝胶设计和制造的主要成分。通过将聚酯和多肽等疏水链段纳入基于PEG的体系中，开发出具有可调节性能的可生物降解的热敏水凝胶，并成为近年来生物材料的研究热点。 对基于PEG的热敏水凝胶的分子设计、性能调节、热凝胶和降解机制以及生物医学应用的总结和讨论可以为设计新的热凝胶系统和扩大其应用范围提供示范蓝图。
京公网安备 11010802027423号