Herein, we describe the scalability and sustainability investigations toward the visible light-mediated amidation of aldehydes with N-chloro-N-sodio-carbamates. The practicality credentials of N-chloro-N-sodio-carbamates for their use in multigram scale amidation reactions are proven by scale-up productions and thermogravimetric analysis. The described amidation, which was previously hampered in sustainability perspectives by the use of α,α,α-trifluorotoluene solvent, is now improved through re-optimizations using ethyl acetate as an alternative green solvent. The generality of multigram scale amidations is demonstrated by the conversion of a selected list of aldehydes, in which the corresponding amides can be isolated in high purity without the need for special purification procedures.

中文翻译：

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N-氯-N-二氨基甲酸酯作为一种实用的酰胺化试剂，在可见光下可扩展和可持续地醛化

在这里，我们描述了对可见光介导的乙酰胺与N-氯-N-磺基氨基甲酸酯酰胺化的可扩展性和可持续性研究。N-氯-N的实用性证明-钠-氨基甲酸酯在多克规模的酰胺化反应中的应用已通过规模生产和热重分析得到了证明。前面描述的酰胺化在可持续性方面由于使用α，α，α-三氟甲苯溶剂而受到阻碍，现在通过使用乙酸乙酯作为替代绿色溶剂的重新优化进行了改进。通过选择的一系列醛的转化证明了克级酰胺化的普遍性，其中可以以高纯度分离出相应的酰胺，而无需特殊的纯化程序。