3D打印PCL/PLGA/HA生物骨组织工程支架的性能,Polymer Composites

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3D打印PCL/PLGA/HA生物骨组织工程支架的性能
Polymer Composites ( IF 4.8 ) Pub Date : 2021-04-19 , DOI: 10.1002/pc.26081
Zhiyong Ma ₁ , Qifan Wang ₂ , Wenjia Xie ₃ , Wenjie Ye ₄ , Linna Zhong ₃ , Jile Huge ₅ , Ying Wang ₂

Affiliation

在骨缺损修复中，由可降解聚合物制成的骨组织工程支架被认为是潜在的骨缺损移植替代品。其中，聚己内酯（PCL）和聚乳酸共乙醇酸（PLGA）在组织工程中应用广泛。PCL具有良好的加工性。然而，PCL 较差的亲水性导致纯 PCL 支架的细胞粘附率较低。PLGA 具有良好的生物学特性。但PLGA在快速降解过程中会产生酸性物质，导致局部pH值偏低，PLGA韧性较差。在这项研究中，PCL 和 PLGA 以不同的比例混合，并添加了 20 wt% 的羟基磷灰石 (HA)。采用3D打印方法制备了具有良好孔结构的PCL/PLGA/HA支架。规则的网格结构使营养物的运输更加方便。支架中的 PCL 组分提高了支架的韧性。由于PLGA的混合，提高了复合支架的亲水性，使支架更有利于细胞粘附。同时，复合支架中所含的 HA 成分提供了 Ca²⁺和PO ₄^3-用于支架，促进复合支架上细胞的成骨分化。由于3D打印制备的PCL/PLGA/HA复合支架在力学和细胞测试中均表现出良好的性能，我们认为该复合支架在骨组织工程领域具有潜在的应用前景。

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Performance of 3D printed PCL/PLGA/HA biological bone tissue engineering scaffold

In the repair of bone defects, bone tissue engineering scaffolds made of degradable polymers are considered as potential bone defect graft substitutes. Among them, polycaprolactone (PCL) and polylactic acid coglycolic acid (PLGA) are widely used in tissue engineering. PCL has good processability. However, the poor hydrophilicity of PCL leads to a lower cell adhesion rate of pure PCL scaffolds. PLGA has good biological properties. However, the production of acidic substances during the rapid degradation of PLGA will result in low-local pH, and PLGA has poor toughness. In this study, PCL and PLGA were mixed in different proportions and 20 wt% hydroxyapatite (HA) was added. A PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The regular grid structure makes the transportation of nutrients more convenient. The PCL component in the scaffold improves the toughness of the scaffold. Due to the mixing of PLGA, the hydrophilicity of the composite scaffold is improved, making the scaffold more conducive to cell adhesion. At the same time, the HA component contained in the composite scaffold provides Ca²⁺ and PO₄³⁻ for the scaffold, which promotes the osteogenic differentiation of cells on the composite scaffold. Since the PCL/PLGA/HA composite scaffold prepared by 3D printing has shown good performance in mechanical and cell tests, we believe that the composite scaffold has potential applications in the field of bone tissue engineering.

更新日期：2021-04-19

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