Sialic acid (SA) is a crucial component of glycoproteins and glycolipids on the cellular membrane, which is essential for maintaining the function of cell membranes, such as cell recognition and communication. Simultaneously, sialic acid plays a significant role in many physiological and pathological processes. Hence, it is urgent to develop a simple and sensitive strategy for determining sialic acid. In this work, a new metal-organic framework called UiO-66-NH₂@B(OH)₂ has been designed and synthesized for the recognition and detection of sialic acid. The boronic acid functional group in UiO-66-NH₂@B(OH)₂ can bind to a diol moiety of the glycerol side chain of sialic acid, which will attenuate or even quench the fluorescence of UiO-66-NH₂@B(OH)₂, thus opening a new road to detect sialic acid. Based on the measurement results, sialic acid can be quantitatively measured in a linear range of 0.05–2.5 mmoL/L with the UiO-66-NH₂@B(OH)₂ probe. The detection limit of sialic acid is as low as 0.025 mmol/L. Furthermore, the boronic-acid functionalized probe UiO-66-NH₂@B(OH)₂ displays high sensitivity and high selectivity to recognize the sialic acid in mouse serum samples. Therefore, the developed UiO-66-NH₂@B(OH)₂ can be used as a promising probe to identify and detect sialic acid in the practical application.

唾液酸（SA）是细胞膜上糖蛋白和糖脂的重要组成部分，对于维持细胞膜的功能（例如细胞识别和交流）至关重要。同时，唾液酸在许多生理和病理过程中起重要作用。因此，迫切需要开发一种简单而灵敏的测定唾液酸的策略。在这项工作中，已经设计并合成了一种新的金属有机骨架，称为UiO-66-NH ₂ @B（OH）₂，用于识别和检测唾液酸。UiO-66-NH ₂ @B（OH）_2中的硼酸官能团可以与唾液酸甘油侧链的二醇部分结合，这将减弱甚至消除UiO-66-NH ₂ @B（OH）₂的荧光，从而开辟了检测唾液酸的新途径。根据测量结果，可以使用UiO-66-NH ₂ @B（OH）₂探针在0.05–2.5 mmoL / L的线性范围内定量测量唾液酸。唾液酸的检出限低至0.025 mmol / L。此外，硼酸官能化探针UiO-66-NH ₂ @B（OH）₂显示出高灵敏度和高选择性，可识别小鼠血清样品中的唾液酸。因此，开发了UiO-66-NH ₂ @B（OH）₂ 在实际应用中可以用作鉴定和检测唾液酸的有前途的探针。