Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process,Macromolecular Bioscience

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Zinc(II)-Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2021-04-16 , DOI: 10.1002/mabi.202100048
Huiting Jia ₁ , Xindong Wang ₁ , Zhaoming Chen ₁ , Shuai Liu ₁ , Tongtong Zhou ₁ , Hao Zhou ₂ , Tianying Guo ₁

Affiliation

Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn²⁺ complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. And the effects of different structural characteristics, such as the number of pyridinamine ligands, the hydrophilic-hydrophobicity of the adjacent groups, on the in vitro transfection performance of the ternary complex are systematically investigated. This ternary hybrid system provides an effective strategy to improve the gene delivery of cationic polymers.

中文翻译：

Zinc (II)-Dipicolylamine 类似物介导的 PEI1.8k/pDNA 载体：配体结构对基因转运过程的影响

二吡啶胺类似物的锌离子络合物，由于含有多吡啶衍生物的Zn ²⁺络合物与聚阳离子在pDNA转运的每个关键步骤中具有很强的协同作用，已被用作介导分子量为1.8 kDa的聚乙烯亚胺（PEI1）的第三组分。 .8k)/DNA 基因传递系统。并系统地研究了吡啶胺配体的数量、相邻基团的亲水-疏水性等不同结构特征对三元复合物体外转染性能的影响。这种三元杂化系统为改善阳离子聚合物的基因传递提供了一种有效的策略。

更新日期：2021-06-21

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