肝巨噬细胞和炎症在非酒精性脂肪肝的生理和病理生理学中,The FEBS Journal

当前位置： X-MOL 学术 › FEBS J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

肝巨噬细胞和炎症在非酒精性脂肪肝的生理和病理生理学中
The FEBS Journal ( IF 5.5 ) Pub Date : 2021-04-15 , DOI: 10.1111/febs.15877
Ronan Thibaut ₁ , Matthew C. Gage ₂ , Inès Pineda‐Torra ₃ , Gwladys Chabrier ₂ , Nicolas Venteclef ₁ , Fawaz Alzaid ₁

Affiliation

非酒精性脂肪性肝病 (NAFLD) 是代谢综合征的肝脏表现，是 2 型糖尿病的常见合并症，与炎症和胰岛素抵抗有重要联系。NAFLD 代表一系列肝脏疾病，从异位脂质储存形式的脂肪变性到非酒精性脂肪性肝炎 (NASH) 的炎症和纤维化。肝脏中的巨噬细胞在维持正常生理下的肝脏稳态以及在 NAFLD 向 NASH 的进展中促进炎症和介导纤维化方面发挥着重要作用。肝巨噬细胞是一组异质的先天免疫细胞，起源于卵黄囊或循环单核细胞，在暴露于富含营养物质和激素的门静脉和胰腺血流中时需要维持免疫耐受。然而，肝巨噬细胞在响应危险信号时发出警报的能力有限。我们现在知道，肝脏中的巨噬细胞在 NAFLD 的整个进展过程中同时发挥炎症和非炎症作用。巨噬细胞反应首先在整合环境刺激的细胞表面受体水平上介导，信号通过细胞中的多个调节水平进行转导，特定的转录程序决定效应器功能。这些效应器功能在确定 NAFLD 的病程中发挥着至关重要的作用，在 NASH 的进展中更是如此。本综述涵盖了最近关于肝巨噬细胞在 NAFLD 中的生理和病理生理作用的报道。

"点击查看英文标题和摘要"

Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, being a common comorbidity of type 2 diabetes and with important links to inflammation and insulin resistance. NAFLD represents a spectrum of liver conditions ranging from steatosis in the form of ectopic lipid storage, to inflammation and fibrosis in nonalcoholic steatohepatitis (NASH). Macrophages that populate the liver play important roles in maintaining liver homeostasis under normal physiology and in promoting inflammation and mediating fibrosis in the progression of NAFLD toward to NASH. Liver macrophages are a heterogenous group of innate immune cells, originating from the yolk sac or from circulating monocytes, that are required to maintain immune tolerance while being exposed portal and pancreatic blood flow rich in nutrients and hormones. Yet, liver macrophages retain a limited capacity to raise the alarm in response to danger signals. We now know that macrophages in the liver play both inflammatory and noninflammatory roles throughout the progression of NAFLD. Macrophage responses are mediated first at the level of cell surface receptors that integrate environmental stimuli, signals are transduced through multiple levels of regulation in the cell, and specific transcriptional programmes dictate effector functions. These effector functions play paramount roles in determining the course of disease in NAFLD and even more so in the progression towards NASH. The current review covers recent reports in the physiological and pathophysiological roles of liver macrophages in NAFLD. We emphasise the responses of liver macrophages to insulin resistance and the transcriptional machinery that dictates liver macrophage function.

更新日期：2021-04-15

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文