Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.,European Journal of Organic Chemistry

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Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-04-16 , DOI: 10.1002/ejoc.202100278
Ashif Yasin Shaikh ₁ , Fredrik Fredrik Björkling ₁ , Peter Eigil Nielsen ₂ , Henrik Franzyk ₃

Affiliation

Fmoc/Boc-protected PNA monomers were efficiently synthesized on a multigram scale and proved compatible with PNA oligomer synthesis by using manual and automated protocols. Screening of coupling conditions included isolation of byproducts and determination of purity by analytical HPLC and MALDI-TOF mass spectrometry; this revealed phosphonium salts as superior coupling reagents for assembly of PNA.

中文翻译：

Fmoc / Boc保护的PNA单体的优化合成及其组装为PNA寡聚物。

Fmoc / Boc保护的PNA单体可在数克范围内高效合成，并通过使用手动和自动方案证明与PNA低聚物合成兼容。偶联条件的筛选包括副产物的分离以及通过分析型HPLC和MALDI-TOF质谱测定纯度；这表明phospho盐是组装PNA的优良偶联剂。

更新日期：2021-05-22

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