Danshen (Salvia miltiorrhiza Bunge) is broadly utilized in traditional Chinese medicine for lung cancer. However, it’s exact effort and mechanism on lung cancer is fully unclear. In this study, we found that dihydroisotanshinone I (DT), a pure compound extracted from danshen, can inhibit the growth of A549 cells and H460 cells. DT also induced apoptosis and ferroptosis in these lung cancer cells. DT also blocking the protein expression of GPX4 (Glutathione peroxidase 4). For in vivo study, DT treatment can inhibit metastasis of A549 cells in the nude mice model without adverse effects on mice. In conclusion, DT inhibited the growth of lung cancer cells through apoptosis and ferroptosis and inhibited metastasis of A549 cells in the nude mice model. Further studies are warranted to validate the findings of this study.

丹参（Salvia miltiorrhiza Bunge）被广泛用于治疗肺癌的中药。然而，它对肺癌的确切作用和机制尚不清楚。在本研究中，我们发现从丹参中提取的纯化合物二氢异丹参酮 I (DT) 可以抑制 A549 细胞和 H460 细胞的生长。DT 还在这些肺癌细胞中诱导细胞凋亡和铁死亡。DT 还阻断 GPX4（谷胱甘肽过氧化物酶 4）的蛋白质表达。在体内研究中，DT治疗可以抑制裸鼠模型中A549细胞的转移，而对小鼠无不良影响。综上所述，在裸鼠模型中，DT通过凋亡和铁死亡抑制肺癌细胞的生长，并抑制A549细胞的转移。需要进一步的研究来验证本研究的结果。