A convenient and practical approach for construction of 3-(2-methoxypyridin-3-yl)-4H-chromen-4-ones has been successfully developed by a one-pot Meinwald rearrangement/intramolecular demethylation annulation reaction sequence with easily accessible epoxides as the starting material. The synthetic protocol is of excellent functional group compatibility under mild reaction conditions, and 3-(2-methoxypyridin-3-yl)-4H-chromen-4-ones were obtained in high yields. Moreover, further derivation successfully furnished more complicated derivatives by Suzuki-Miyaura cross-coupling reaction which may provide a promising potential application in exploring biological activity of 3-aryl-4H-chromen-4-ones.

中文翻译：

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构建 3-(2-Methoxypyridin-3-yl)-4 的一锅法

通过单锅 Meinwald 重排/分子内去甲基化环化反应序列成功地开发了一种构建 3-(2-甲氧基吡啶-3-基)-4 H -chromen-4-ones的方便实用的方法，环氧化物为起始材料。该合成方案在温和的反应条件下具有优异的官能团相容性，并且以高收率获得了3-(2-甲氧基吡啶-3-基)-4 H -chromen-4-ones。此外，通过 Suzuki-Miyaura 交叉偶联反应进一步衍生成功地提供了更复杂的衍生物，这可能为探索 3-aryl-4 H -chromen-4-ones 的生物活性提供有前景的潜在应用。