Hierarchical Dendritic Mesoporous TiO2 Nanocomposites for Highly Selective Enrichment of Endogenous Phosphopeptides,ACS Sustainable Chemistry & Engineering

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Hierarchical Dendritic Mesoporous TiO2 Nanocomposites for Highly Selective Enrichment of Endogenous Phosphopeptides
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-04-09 , DOI: 10.1021/acssuschemeng.0c08210
Chenlu Pu ₁ , Hongli Zhao ₁ , Yayun Hong ₁ , Zhenxing Wang ₁ , Yu Zheng ₁ , Minbo Lan _{1,

2}

Affiliation

The uniform growth of metal oxides into mesoporous nanostructures with controllable orientations is challenging but of significance. Here, a polydopamine (PDA)-induced oriented growth strategy is proposed to uniformly grow metal ions into mesoporous metal oxides with controllable orientation. Two mesoporous nanostructures (3D hierarchical dendritic nanostructures and 2D nanosheets) were constructed by this strategy. It is worth emphasizing that the 3D hierarchical mesoporous nanostructures (DMSNs@TiO₂) are formed by constructing single-layered porous TiO₂ in dendritic mesoporous tunnels, which is different from the previously reported generation of hierarchical pores inside frameworks or accumulation of various channels. In such a pore system, small pores are connected by large pores, thereby enhancing the accessibility of pores. DMSNs@TiO₂ with a large surface area and connected hierarchical pore structure exhibit highly improved phosphopeptide enrichment performance compared with commercial TiO₂ and single-pored TiO₂. Especially for real samples such as human saliva, DMSNs@TiO₂ captured 49 endogenous phosphopeptides from 1 μL of saliva, demonstrating their broad prospects in phosphopeptidomics analysis.

中文翻译：

分层树状介孔TiO ₂纳米复合材料对内源性磷酸肽的高度选择性富集

将金属氧化物均匀地生长成具有可控取向的中孔纳米结构是具有挑战性的，但具有重要意义。在此，提出了一种由聚多巴胺（PDA）诱导的定向生长策略，以将金属离子均匀地生长为具有可控定向的中孔金属氧化物。通过该策略构建了两个介孔纳米结构（3D分层树状纳米结构和2D纳米片）。值得强调的是，通过构造单层多孔TiO ₂形成了3D分层中孔纳米结构（DMSNs @ TiO ₂）在树枝状介孔隧道中，它不同于先前报道的在框架内部生成分层孔隙或各种通道堆积的现象。在这样的孔系统中，小孔通过大孔连接，从而提高了孔的可及性。DMSNs @的TiO ₂具有大的表面积，并连接分级孔结构表现出高度改善的磷酸富集性能与商业的TiO相比₂和单倾的TiO ₂。特别是对于人类唾液等真实样品，DMSNs @ TiO ₂从1μL唾液中捕获了49种内源性磷酸肽，证明了其在磷肽组学分析中的广阔前景。

更新日期：2021-05-03

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