Plasmonic Optical Tweezers for Particle Manipulation: Principles, Methods, and Applications,ACS Nano

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Plasmonic Optical Tweezers for Particle Manipulation: Principles, Methods, and Applications
ACS Nano ( IF 15.8 ) Pub Date : 2021-04-09 , DOI: 10.1021/acsnano.1c00466
Yatao Ren _{1,

2} , Qin Chen ₁ , Mingjian He ₂ , Xiangzhi Zhang ₃ , Hong Qi ₂ , Yuying Yan _{1,

3}

Affiliation

Inspired by the idea of combining conventional optical tweezers with plasmonic nanostructures, a technique named plasmonic optical tweezers (POT) has been widely explored from fundamental principles to applications. With the ability to break the diffraction barrier and enhance the localized electromagnetic field, POT techniques are especially effective for high spatial-resolution manipulation of nanoscale or even subnanoscale objects, from small bioparticles to atoms. In addition, POT can be easily integrated with other techniques such as lab-on-chip devices, which results in a very promising alternative technique for high-throughput single-bioparticle sensing or imaging. Despite its label-free, high-precision, and high-spatial-resolution nature, it also suffers from some limitations. One of the main obstacles is that the plasmonic nanostructures are located over the surfaces of a substrate, which makes the manipulation of bioparticles turn from a three-dimensional problem to a nearly two-dimensional problem. Meanwhile, the operation zone is limited to a predefined area. Therefore, the target objects must be delivered to the operation zone near the plasmonic structures. This review summarizes the state-of-the-art target delivery methods for the POT-based particle manipulating technique, along with its applications in single-bioparticle analysis/imaging, high-throughput bioparticle purifying, and single-atom manipulation. Future developmental perspectives of POT techniques are also discussed.

中文翻译：

用于粒子处理的等离子光镊：原理，方法和应用

受到将常规光镊与等离子纳米结构相结合的想法的启发，从基本原理到应用，人们广泛探索了一种名为等离子光镊（POT）的技术。具有突破衍射障碍和增强局部电磁场的能力，POT技术对于从小生物粒子到原子的纳米级甚至亚纳米级物体的高空间分辨率操纵特别有效。此外，POT可以很容易地与其他技术（例如片上实验室设备）集成在一起，这为高通量单生物颗粒传感或成像提供了非常有前途的替代技术。尽管它具有无标签，高精度和高空间分辨率的特性，但它也受到一些限制。主要障碍之一是等离子体纳米结构位于基板表面上方，这使得生物粒子的处理从三维问题转变为几乎二维问题。同时，操作区域被限制在预定区域。因此，必须将目标物体传送到等离激元结构附近的操作区域。这篇综述总结了基于POT的粒子操纵技术的最新目标传递方法，以及其在单生物粒子分析/成像，高通量生物粒子纯化和单原子操纵中的应用。还讨论了POT技术的未来发展前景。这使得生物粒子的处理从三维问题转变为几乎二维问题。同时，操作区域被限制在预定区域。因此，必须将目标物体传送到等离子体结构附近的操作区域。这篇综述总结了基于POT的粒子操纵技术的最新目标传递方法，以及其在单生物粒子分析/成像，高通量生物粒子纯化和单原子操纵中的应用。还讨论了POT技术的未来发展前景。这使得生物粒子的处理从三维问题转变为几乎二维问题。同时，操作区域被限制在预定区域。因此，必须将目标物体传送到等离激元结构附近的操作区域。这篇综述总结了基于POT的粒子操纵技术的最新目标传递方法，以及其在单生物粒子分析/成像，高通量生物粒子纯化和单原子操纵中的应用。还讨论了POT技术的未来发展前景。这篇综述总结了基于POT的粒子操纵技术的最新目标传递方法，以及其在单生物粒子分析/成像，高通量生物粒子纯化和单原子操纵中的应用。还讨论了POT技术的未来发展前景。这篇综述总结了基于POT的粒子操纵技术的最新目标传递方法，以及其在单生物粒子分析/成像，高通量生物粒子纯化和单原子操纵中的应用。还讨论了POT技术的未来发展前景。

更新日期：2021-04-28

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