N⁶-methyladenosine (m⁶A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability more than 200 nt in length, play an important role in epigenetic modification, mRNA transcription, splicing, stability, translation, and other biological functions. Extensive studies have shown that both m⁶A modification and lncRNAs are involved in the pathogenesis of various diseases, such as kinds of cancers, heart failure, Alzheimer’s disease, periodontitis, human abdominal aortic aneurysm, and obesity. To date, m⁶A modification has been identified as an important biological function in enrichment and regulation of lncRNAs. In this review, we summarize the role of m⁶A modification in the regulation and function of tumor-related lncRNAs. Moreover, we discuss the potential applications and possible future directions in the field.

N ^6-甲基腺苷（m ⁶ A）是真核细胞中最丰富的修饰，它调节RNA转录，加工，剪接，降解和翻译。长的非编码RNA（lncRNA），作为无或有限的蛋白质编码能力，长度超过200 nt的转录产物，在表观遗传修饰，mRNA转录，剪接，稳定性，翻译和其他生物学功能中起着重要作用。大量研究表明，m ⁶ A修饰和lncRNA均参与多种疾病的发病机制，例如各种癌症，心力衰竭，阿尔茨海默氏病，牙周炎，人腹主动脉瘤和肥胖症。迄今为止，m ⁶已经鉴定出修饰是lncRNA的富集和调节中的重要生物学功能。在这篇综述中，我们总结了m ⁶ A修饰在肿瘤相关lncRNA的调控和功能中的作用。此外，我们讨论了该领域的潜在应用和可能的未来方向。