Asymmetric Synthesis of P-Stereogenic Secondary Phosphine-Boranes by an Unsymmetric Bisphosphine Pincer-Nickel Complex,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Asymmetric Synthesis of P-Stereogenic Secondary Phosphine-Boranes by an Unsymmetric Bisphosphine Pincer-Nickel Complex
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-04-09 , DOI: 10.1021/jacs.1c02772
Chuanyong Wang ₁ , Kesheng Huang ₁ , Jie Ye ₁ , Wei-Liang Duan ₁

Affiliation

The first highly enantioselective catalytic synthesis of P-stereogenic secondary phosphine-boranes was realized by the asymmetric addition of primary phosphine to electron-deficient alkenes with a newly developed unsymmetric bisphosphine (PCP′) pincer-nickel complex. Various P-stereogenic secondary phosphine-boranes were obtained in 57–92% yields with up to 99% ee and >20:1 dr. The follow-up alkylation upon P–C bond formation with alkyl halides provided a practical way to access P-chiral compounds with diverse functional groups.

中文翻译：

不对称的双膦夹钳-镍配合物不对称合成P-立体异构的次膦-硼烷

通过使用新开发的不对称双膦（PCP'）钳-镍络合物将伯膦不对称加成至缺电子烯烃中，实现了P-立体生成仲膦-硼烷的第一个高对映选择性催化合成。以57-92％的收率获得了各种P-立体异构仲膦-硼烷，ee高达99％，dr> 20：1。与烷基卤形成P–C键后的后续烷基化为获得具有不同官能团的P-手性化合物提供了一种实用的方法。

更新日期：2021-04-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南