Background: Cancer has become the second leading cause of death worldwide. Despite of the availability of significant number of anticancer agents, cancer is still incurable especially at the last stages. Remarkable targets for anticancer research and drug discovery are heterocyclic compounds, and among them, superior effect has been shown by the nitrogen containing compounds than non-nitrogen containing compounds. Nicotinic acid, a nitrogen containing moiety and its derivatives have gained an immense importance in the development of anticancer drugs owing to the wide variety of biological properties displayed by them.

Objective: The objective of this review is to provide researchers the information about various synthetic approaches used for the synthesis of anticancer drugs of nicotinic acid from 2001 onwards and to reveal their application and importance in the treatment of this dreadful disease.

Conclusion: As indicated by this review, considerable work has been done in terms of synthesis and investigation of anticancer potential of nicotinamide derivatives. The information provided in this article may be of great value for the researchers seeking to develop efficient anticancer drugs.

背景：癌症已成为全球第二大死因。尽管有大量抗癌剂可用，但癌症仍然无法治愈，尤其是在最后阶段。抗癌研究和药物发现的显着目标是杂环化合物，其中含氮化合物比不含氮化合物显示出更好的效果。烟酸，一种含氮部分及其衍生物，由于其表现出的多种生物学特性，在抗癌药物的开发中获得了巨大的重要性。

目的：本综述的目的是为研究人员提供有关从 2001 年起用于合成烟酸抗癌药物的各种合成方法的信息，并揭示它们在治疗这种可怕疾病中的应用和重要性。

结论：正如本综述所示，在合成和研究烟酰胺衍生物的抗癌潜力方面已经做了大量工作。本文提供的信息可能对寻求开发高效抗癌药物的研究人员具有重要价值。