氟哌啶醇诱导的僵住症作为帕金森病的动物模型：实验研究的系统评价,European Journal of Neuroscience

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氟哌啶醇诱导的僵住症作为帕金森病的动物模型：实验研究的系统评价
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-04-05 , DOI: 10.1111/ejn.15222
Isabelle Waku ₁ , Mylena S Magalhães ₁ , Camila O Alves _{1,

2} , Amanda R de Oliveira _{1,

2}

Affiliation

迄今为止，已经开发了几种有用的帕金森病动物模型。氟哌啶醇诱发的僵住症通常用作啮齿动物模型，用于研究在帕金森病和相关疾病中观察到的运动障碍以及筛选潜在的抗帕金森病化合物。本系统评价的目的是确定使用氟哌啶醇诱导的僵住症模型治疗帕金森症的出版物，并探讨这些研究中的方法学特征和主要问题。通过访问三个不同数据库中的文章，对文献进行了仔细的系统搜索：Web of Science、PubMed 和 SCOPUS。研究的选择和纳入是基于摘要和随后的全文分析进行的。数据提取包括研究的目标，研究设计和感兴趣的结果。255 篇文章被纳入该综述。出版年份从 1981 年到 2020 年不等。大多数研究使用该模型来探索帕金森病的潜在治疗效果。尽管所使用的方法学特征各不相同，但大多数研究都使用 Wistar 大鼠作为实验对象。氟哌啶醇的最常用剂量为 1.0 mg/kg，单杠试验最常用于评估僵住症。此处提供的数据为使用氟哌啶醇诱导的僵住症模型设计帕金森病临床前研究的循证方法提供了框架。该模型已被成功地常规使用，并且可能会继续在寻找下一代帕金森病治疗干预措施的过程中发挥关键作用。

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Haloperidol-induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies

Several useful animal models for parkinsonism have been developed so far. Haloperidol-induced catalepsy is often used as a rodent model for the study of motor impairments observed in Parkinson's disease and related disorders and for the screening of potential antiparkinsonian compounds. The objective of this systematic review is to identify publications that used the haloperidol-induced catalepsy model for parkinsonism and to explore the methodological characteristics and the main questions addressed in these studies. A careful systematic search of the literature was carried out by accessing articles in three different databases: Web of Science, PubMed and SCOPUS. The selection and inclusion of studies were performed based on the abstract and, subsequently, on full-text analysis. Data extraction included the objective of the study, study design and outcome of interest. Two hundred and fifty-five articles were included in the review. Publication years ranged from 1981 to 2020. Most studies used the model to explore the effects of potential treatments for parkinsonism. Although the methodological characteristics used are quite varied, most studies used Wistar rats as experimental subjects. The most frequent dose of haloperidol used was 1.0 mg/kg, and the horizontal bar test was the most used to assess catalepsy. The data presented here provide a framework for an evidence-based approach to the design of preclinical research on parkinsonism using the haloperidol-induced catalepsy model. This model has been used routinely and successfully and is likely to continue to play a critical role in the ongoing search for the next generation of therapeutic interventions for parkinsonism.

更新日期：2021-06-09

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