Biogenetic Acellular Dermal Matrix Maintaining Rich Interconnected Microchannels for Accelerated Tissue Amendment,ACS Applied Materials & Interfaces

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Biogenetic Acellular Dermal Matrix Maintaining Rich Interconnected Microchannels for Accelerated Tissue Amendment
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-04-05 , DOI: 10.1021/acsami.1c00420
Yixin Wang _{1,

2} , Fei Lu _{1,

2} , Enling Hu _{1,

2} , Kun Yu _{1,

2} , Jiwei Li ₃ , Rong Bao ₄ , Fangyin Dai _{1,

2} , Guangqian Lan _{1,

2} , Ruiqi Xie _{1,

2}

Affiliation

Given that many people suffer from extensive skin damage, wound repair has drawn tremendous attention in research. Among the various assistant dressing materials that promote healing, a porcine acellular dermal matrix (PADM), as a skin substitute, can efficiently accelerate healing by promoting cell migration and proliferation. However, a simple, low-cost preparation process remains a challenge facing PADM development, particularly because of the inferior elasticity. To overcome these drawbacks, a CaCl₂–ethanol–H₂O solution (ternary solution) combined with an additional enzyme treatment was used to obtain a transparent, porous, and elastic PADM that retained the major extracellular matrix composition of the dermis. Our results indicated that alterations in the fiber organization and secondary structural changes in the collagen occurred after treatment. Furthermore, the in vivo wound healing and histological analyses clearly revealed an extremely expedited wound repair process following the application of the biocompatible PADM. In conclusion, this study provides new insights into the development of a transparent PADM with a porous structure and good elasticity that can be used as a skin substitute to accelerate the wound healing process. Moreover, this effective technique could potentially be used to extrapolate other decellularized materials in the future.

中文翻译：

生物遗传脱细胞真皮基质维持丰富的互连微通道以加速组织修复

鉴于许多人遭受广泛的皮肤损伤，伤口修复在研究中引起了极大的关注。在各种促进愈合的辅助敷料材料中，猪脱细胞真皮基质（PADM）作为皮肤替代品，可以通过促进细胞迁移和增殖来有效加速愈合。然而，简单、低成本的制备过程仍然是 PADM 开发面临的挑战，特别是因为弹性较差。为了克服这些缺点，CaCl ₂ -乙醇-H ₂O 溶液（三元溶液）与额外的酶处理相结合，用于获得透明、多孔且有弹性的 PADM，它保留了真皮的主要细胞外基质成分。我们的结果表明，治疗后发生了纤维组织的改变和胶原蛋白的二级结构变化。此外，体内伤口愈合和组织学分析清楚地表明，在应用生物相容性 PADM 后，伤口修复过程极其迅速。总之，这项研究为开发具有多孔结构和良好弹性的透明 PADM 提供了新的见解，该 PADM 可用作皮肤替代品以加速伤口愈合过程。此外，这种有效的技术可能会在未来用于推断其他脱细胞材料。

更新日期：2021-04-14

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