Synthesis of Phenanthridine and Quinoxaline Derivatives via Copper-Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides,Chinese Journal of Chemistry

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Synthesis of Phenanthridine and Quinoxaline Derivatives via Copper-Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2021-04-01 , DOI: 10.1002/cjoc.202100050
Qi Liang ₁ , Long Lin ₁ , Guodong Li ₁ , Xianqiang Kong ₂ , Bo Xu ₁

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A copper-catalyzed radical cyclization of cyclobutanone oxime esters and vinyl azide is described. This method provides facile access to cyanoalkyl-substituted phenanthridines and quinoxalines with excellent isolated yields. Moreover, these reactions proceed under mild conditions with a board substrate scope and excellent functional group tolerance.