Chiral Recognition by Flexible Coordination Polymers of Ag+ with a Cysteine-Based Chiral Thiol Ligand That Bears a Binding Site,Inorganic Chemistry

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Chiral Recognition by Flexible Coordination Polymers of Ag+ with a Cysteine-Based Chiral Thiol Ligand That Bears a Binding Site
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2021-03-31 , DOI: 10.1021/acs.inorgchem.1c00104
Su-Li Dong ₁ , Yan Xu ₁ , Yin-Zhu Chen ₁ , Xiao-Sheng Yan ₁ , Zhao Li ₁ , Jian-Wei Xie ₂ , Yun-Bao Jiang ₁

Affiliation

We report a new scheme for chiral recognition using coordination polymers of Ag⁺ with a chiral thiol ligand that contains a binding group. N-Benzoyl-l-cysteine ethyl ester equipped with a boronic acid group at the para position of the phenyl ring forms coordination polymers with Ag⁺ in alkaline aqueous solutions that exhibit excellent selectivity toward a d-glucose enantiomer over l-glucose, while the coordination polymers from the d-cysteine-based thiol ligand are specific for l-glucose. It is assumed that a conformation change occurs upon interaction of a saccharide molecule with the polymeric chain receptor, for which the next binding is promoted, leading to the highly effective chiral recognition, despite the flexible nature of the polymeric receptor.

中文翻译：

Ag ⁺与带有结合位点的基于半胱氨酸的手性硫醇配体的柔性配位聚合物的手性识别

我们报告了一种新的手性识别方案，其中使用了Ag ⁺与含有一个结合基团的手性硫醇配体的配位聚合物。在苯环的对位带有硼酸基团的N-苄基-1-半胱氨酸乙酯在碱性水溶液中与Ag ⁺形成配位聚合物，相对于1-葡萄糖，其对d-葡萄糖对映异构体具有优异的选择性，而基于d-半胱氨酸的硫醇配体的配位聚合物对l具有特异性-葡萄糖。假定在糖分子与聚合物链受体相互作用时发生构象变化，尽管该聚合物受体具有柔性，但其促进下一个结合，导致高效的手性识别。

更新日期：2021-04-19

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