Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-03-31 , DOI: 10.1002/adfm.202100738
Ge Gao ₁ , Xianbao Sun ₁ , Gaolin Liang ₁

Affiliation

Photothermal therapy (PTT), which utilizes near-infrared light-absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild-temperature PTT, which circumvents the limitations of conventional PTT (e.g., thermoresistance and adverse effects), is emerging and shows great potential in the forthcoming clinical applications. However, mild-temperature PTT without adjuvant therapy is not able to completely eradicate tumors because its therapeutic efficacy is dramatically impaired by its inferior heat intensity. As a result, strategies capable of enhancing the anticancer efficacy of mild-temperature PTT are urgently necessitated, which mainly rely on on-demand fabrication of functionalized nanoagents. In this review, the strategies of nanoagent-promoted mild-temperature PTT are highlighted. Furthermore, challenges and opportunities in this field are rationally proposed, and hopefully people can be encouraged by this promising anticancer therapy.

中文翻译：

纳米试剂促进的温和温度光热疗法用于癌症治疗

利用近红外光吸收剂消融肿瘤的光热疗法 (PTT) 已成为一种极具前景的抗癌策略，并在近年来获得了大量临床试验。温和的 PTT 克服了传统 PTT 的局限性（例如，耐热性和不良反应），正在出现并在即将到来的临床应用中显示出巨大的潜力。然而，没有辅助治疗的温和 PTT 不能完全根除肿瘤，因为其较低的热强度显着削弱了其治疗效果。因此，迫切需要能够增强温和温度 PTT 抗癌功效的策略，这主要依赖于功能化纳米试剂的按需制造。在这次审查中，突出了纳米试剂促进的温和温度 PTT 的策略。此外，该领域的挑战和机遇也被理性提出，希望这种有前景的抗癌疗法能够鼓舞人们。

更新日期：2021-03-31

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南