ABSTRACT

Wheat consists mainly of gluten with about 30% gliadin and 50% glutenin, which give gluten its unique viscoelastic properties and also mainly associated with the cause of celiac disease. Although the hydrolysis of gluten has been characterized, the discovery of new gluten-based peptides with high affinity toward T-cells is challenging. Currently, the highly immunogenic 33-mer gliadin peptide is considered to be the main cause of celiac disease. Thus, having consistent data for different gluten peptides with their respective immunogenicity is urgently needed. This report summarizes the various immunogenic gluten peptides identified, and the ingestion of specific gliadin peptide leading to the onset of CD, caused by the immunogenic α/β-gliadins especially in relation to the binding sites on HLA-DQ2 and HLA-DQ8.

摘要

小麦主要由含有约 30% 麦醇溶蛋白和 50% 麦谷蛋白的面筋组成，这使面筋具有独特的粘弹性，并且主要与乳糜泻的病因有关。尽管已经对谷蛋白的水解进行了表征，但发现对 T 细胞具有高亲和力的新的基于谷蛋白的肽具有挑战性。目前，高度免疫原性的 33-mer 醇溶蛋白肽被认为是乳糜泻的主要原因。因此，迫切需要针对具有各自免疫原性的不同面筋肽获得一致的数据。本报告总结了鉴定的各种免疫原性麸质肽，以及摄入导致 CD 发作的特定麦醇溶蛋白肽，这是由免疫原性 α/β-麦醇溶蛋白引起的，特别是与 HLA-DQ2 和 HLA-DQ8 上的结合位点有关。