The use of traditional chemical catalysis to produce chemicals has a series of drawbacks, such as high dependence on fossil resources, high energy consumption, and environmental pollution. With the development of synthetic biology and metabolic engineering, the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial fermentation. This review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial production. In addition, this review also summarizes several strategies for effectively regulating microbial cell metabolism. These strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism, and promote the efficient production of target chemicals by microorganisms.

使用传统的化学催化生产化学药品具有一系列缺点，例如对化石资源的高度依赖，高能耗和环境污染。随着合成生物学和代谢工程学的发展，通过建设高效的微生物细胞工厂将可再生生物质原料用于化学合成，是替代传统化学催化和传统微生物发酵的绿色途径。这篇综述主要总结了几种类型的散装化学品和高附加值化学品，它们利用代谢工程和合成生物学策略来实现有效的微生物生产。此外，本综述还总结了有效调节微生物细胞代谢的几种策略。