Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway,Journal of Agricultural and Food Chemistry

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Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-03-31 , DOI: 10.1021/acs.jafc.0c06695
Yang Xu ₁ , Huihui Ke ₁ , Yuting Li ₁ , Lianghua Xie ₁ , Hongming Su ₁ , Jiahong Xie ₁ , Jianling Mo ₂ , Wei Chen _{1,

2,

3}

Affiliation

Nonalcoholic fatty liver disease (NAFLD) has become a universal health issue, whereas there is still a lack of widely accepted therapy until now. Clinical research studies have shown that blueberry could effectively regulate the lipid metabolism, thereby improving obesity-related metabolic syndromes; however, the specific active substances and mechanisms remain unclear. Herein, the effects of the major 10 kinds of anthocyanins from blueberry against NAFLD were investigated using an free fatty acid (FFA)-induced cell model. Among these anthocyanins, malvidin-3-O-glucoside (M3G) and malvidin-3-O-galactoside (M3Ga) could remarkably ameliorate FFA-induced lipid accumulation. Besides, M3G and M3Ga also inhibited oxidative stress via suppressing reactive oxygen species and superoxide anion overproduction, increasing glutathione levels, and enhancing activities of antioxidant enzymes. Further studies unveiled that the representative anthocyanin M3G-upregulated transcription factor EB (TFEB)-mediated lysosomal function possibly interacted with TFEB and activated the Nrf2/ARE (antioxidant responsive element) signaling pathway. Overall, this study enriched the knowledge about the health-promoting effects of blueberry anthocyanins against NAFLD and provided ideas for the development of functional foods of blueberry anthocyanins.

中文翻译：

蓝莓中的Malvidin-3- O-葡萄糖苷可通过调节转录因子EB介导的溶酶体功能并激活Nrf2 / ARE信号通路来缓解非酒精性脂肪肝疾病

非酒精性脂肪性肝病（NAFLD）已成为普遍的健康问题，但是到目前为止，仍然缺乏广泛接受的疗法。临床研究表明，蓝莓可以有效调节脂质代谢，从而改善肥胖相关的代谢综合征。但是，具体的活性物质和机理尚不清楚。在此，使用游离脂肪酸（FFA）诱导的细胞模型研究了蓝莓中主要的10种花色苷对NAFLD的作用。在这些花色苷中，malvidin-3- O-葡萄糖苷（M3G）和malvidin-3- O-半乳糖苷（M3Ga）可以显着改善FFA诱导的脂质蓄积。此外，M3G和M3Ga还通过以下方式抑制氧化应激抑制活性氧和超氧阴离子的过量产生，增加谷胱甘肽水平，增强抗氧化酶的活性。进一步的研究表明，代表性的花色素苷M3G上调的转录因子EB（TFEB）介导的溶酶体功能可能与TFEB相互作用并激活了Nrf2 / ARE（抗氧化反应元件）信号传导途径。总的来说，这项研究丰富了有关蓝莓花色苷对NAFLD的健康促进作用的知识，并为开发蓝莓花色苷功能性食品提供了思路。

更新日期：2021-04-29

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