Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles,Organic Letters

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Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles
Organic Letters ( IF 4.9 ) Pub Date : 2021-03-29 , DOI: 10.1021/acs.orglett.1c00655
Hu-Lin Zhu ₁ , Fan-Lin Zeng ₁ , Xiao-Lan Chen ₁ , Kai Sun ₁ , Hao-Cong Li ₁ , Xiao-Ya Yuan ₁ , Ling-Bo Qu ₁ , Bing Yu ₁

Affiliation

A general and metal-free visible-light-induced decarboxylative arylation procedure at room temperature was described for the construction of acylated heterocyclic derivatives, such as benzimidazo/indolo[2,1-a]isoquinolin-6(5H)-ones, aroylazaspiro[4.5]trienones, thioflavones, and so on. This practical arylation procedure was conducted by using 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN) as a photocatalyst under mild conditions, which avoided the use of an additional base, traditional heating, and metal reagents.

中文翻译：

α-酮酸的酰基自由基：杂环的无金属可见光促进酰化作用

描述了一种在室温下通用且无金属的可见光诱导的脱羧芳基化方法，用于构建酰化杂环衍生物，例如苯并咪唑/吲哚并[ 2,1 - a ]异喹啉-6（5 H）-ones，芳酰基azaspiro [4.5]三烯酮，硫代黄酮等。通过在温和的条件下使用2,4,5,6-四（9 H-咔唑-9-基）间苯二甲腈（4CzIPN）作为光催化剂来进行该实用的芳基化步骤，避免了使用额外的碱，传统的加热，和金属试剂。

更新日期：2021-04-16

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