用于皮肤感染的抗菌光动力金纳米粒子,ACS Applied Bio Materials

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用于皮肤感染的抗菌光动力金纳米粒子
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-03-19 , DOI: 10.1021/acsabm.0c01505
Lin Qiu ₁ , Cheng Wang ₁ , Min Lan ₁ , Qianqian Guo ₁ , Xuancheng Du ₂ , Shuwen Zhou ₁ , Pengfei Cui ₁ , Tingting Hong ₁ , Pengju Jiang ₁ , Jianhao Wang ₁ , Jiang Xia ₃

Affiliation

对皮肤的损伤或损伤会造成容易受到细菌感染的伤口，进而延缓皮肤再生和伤口愈合的过程。在严重烧伤患者和患有糖尿病等慢性疾病的患者中，多重耐药细菌的皮肤感染可能是致命的。因此，一种通过不同于抗生素的机制有效根除细菌感染的广谱疗法备受追捧。我们成功合成了抗菌光动力金纳米粒子（AP-AuNPs），它是抗菌光动力肽和聚（乙二醇）（PEG）稳定的金纳米粒子的自组装纳米复合材料。AP-AuNPs 表现出水和光稳定性、令人满意的活性氧 (ROS) 生成以及对革兰氏阳性菌的显着抗菌作用光照射下的金黄色葡萄球菌和革兰氏阴性大肠杆菌。此外，合成的纳米复合材料在体外显着抑制细菌生长和生物膜形成。光动力抗菌治疗加速金黄色葡萄球菌的伤口愈合速度感染，模仿葡萄球菌皮肤感染。利用肽的杀菌作用、光敏剂的光动力效应和金纳米粒子的多价簇在光照射下的最大抗菌作用，我们合成了 AP-AuNPs 作为皮肤感染的伤口敷料纳米材料，以促进伤口愈合. 我们的研究结果表明，在管理由受损皮肤组织引起的细菌感染方面，这是一种很有前景的策略，我们的同行尚未充分探索这一方面。

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Antibacterial Photodynamic Gold Nanoparticles for Skin Infection

Damage or injury to the skin creates wounds that are vulnerable to bacterial infection, which in turn retards the process of skin regeneration and wound healing. In patients with severe burns and those with chronic diseases, such as diabetes, skin infection by multidrug-resistant bacteria can be lethal. Therefore, a broad-spectrum therapy to effectively eradicate bacterial infection through a mechanism different from that of antibiotics is much sought after. We successfully synthesized antibacterial photodynamic gold nanoparticles (AP-AuNPs), which are self-assembled nanocomposites of an antibacterial photodynamic peptide and poly(ethylene glycol) (PEG)-stabilized AuNPs. The AP-AuNPs exhibited aqueous and light stability, a satisfactory generation of reactive oxygen species (ROS), and a remarkable antibacterial effect toward both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli upon light irradiation. Moreover, the synthesized nanocomposites significantly inhibited bacterial growth and biofilm formation in vitro. Photodynamic antibacterial treatment accelerated the wound-healing rate in S. aureus infections, mimicking staphylococcal skin infections. Using a combination of the bactericidal effect of a peptide, the photodynamic effect of a photosensitizer, and the multivalency clustering on AuNPs for maximal antibacterial effect under light irradiation, we synthesized AP-AuNPs as a wound-dressing nanomaterial in skin infections to promote wound healing. Our findings indicate a promising strategy in the management of bacterial infections resulting from damaged skin tissue, an aspect that has not been fully explored by our peers.

更新日期：2021-04-19

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