Phosphonium Ylide-Mediated Programmable Fluorination to Access Mono- and Difluoromethylarenes,Organic Letters

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Phosphonium Ylide-Mediated Programmable Fluorination to Access Mono- and Difluoromethylarenes
Organic Letters ( IF 4.9 ) Pub Date : 2021-03-19 , DOI: 10.1021/acs.orglett.1c00457
Yu Zheng ₁ , Zhen-Zhen Xie ₁ , Xian-Chen He ₁ , Yan-Shan Chen ₁ , Wen-Shuo Cheng ₁ , Kai Chen ₁ , Hao-Yue Xiang ₁ , Xiao-Qing Chen ₁ , Hua Yang ₁

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Compounds bearing fluorinated moieties are pervasive in a wide range of pharmaceuticals and agrochemicals. The installation of fluorinated units is a persistently vital task in synthetic chemistry, where facile and manipulable assays are highly demanding. Herein, we establish a general and programmable fluorination strategy for the modular assembly of mono- and difluoromethylarenes through the controllable deprotonation and fluorination of phosphonium ylides. Moreover, the rational combination of the reaction sequence allows the rapid construction of diversified fluorine-containing arenes.

中文翻译：

磷鎓叶立德介导的可编程氟化，以访问单和二氟甲基芳烃

带有氟化部分的化合物在许多药物和农用化学品中普遍存在。氟化单元的安装在合成化学中是一项至关重要的任务，在合成化学中，对简便易行的测定法的要求很高。在这里，我们通过establish的可控去质子化和氟化为单-和二氟甲基芳烃的模块化组装建立了通用且可编程的氟化策略。而且，反应顺序的合理组合允许快速构建多样化的含氟芳烃。

更新日期：2021-04-02

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