A synthetic approach to the modification of the drug Riluzole with pharmacologically active fragments (adamantane, carbazole, tetrahydrocarbazole, γ-carboline, and phenothiazine) was proposed, which is based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with alkyne-containing derivatives of Riluzole.

中文翻译：

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炔基叠氮化物点击反应中的2-炔丙基氨基-6-（三氟甲氧基）苯并[d]噻唑与药理活性片段

提出了一种基于铜催化的炔-叠氮化物1,3-偶极环加成反应的合成方法，以药物活性片段（金刚烷，咔唑，四氢咔唑，γ-咔啉和吩噻嗪）修饰Riluzole。含药效基团与利鲁唑的含炔烃衍生物。