Recent Advances in Catalytic Asymmetric Construction of Atropisomers,Chemical Reviews

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Recent Advances in Catalytic Asymmetric Construction of Atropisomers
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-03-27 , DOI: 10.1021/acs.chemrev.0c01306
Jun Kee Cheng ₁ , Shao-Hua Xiang _{1,

2} , Shaoyu Li _{1,

2} , Liu Ye _{1,

2} , Bin Tan ₁

Affiliation

Atropisomerism is a stereochemical behavior portrayed by three-dimensional molecules that bear rotationally restricted σ bond. Akin to the well-represented point-chiral molecules, atropisomerically chiral compounds are finding increasing utilities in many disciplines where molecular asymmetry is influential. This provides steady demand on atroposelective synthesis, where numerous synthetic pursuits have been rewarded with conceptually novel and streamlined methods while expanding the structural diversity of atropisomers. This review summarizes key achievements in stereoselective preparation of biaryl, heterobiaryl, and nonbiaryl atropisomers documented between 2015 and 2020. Emphasis is placed on the synthetic strategies for each structural class, while examples are cited to illustrate the potential applications of the accessed atropochiral targets.

中文翻译：

阻转异构体催化不对称构建的新进展

阻转异构是由带有旋转受限 σ 键的三维分子描绘的立体化学行为。类似于代表性的点手性分子，阻转异构手性化合物在许多分子不对称有影响的学科中越来越有用。这为阻转选择性合成提供了稳定的需求，其中许多合成追求获得了概念新颖和简化的方法，同时扩大了阻转异构体的结构多样性。本综述总结了 2015 年至 2020 年间记录的联芳基、杂联芳基和非联芳基阻转异构体立体选择性制备的主要成就。重点放在每个结构类别的合成策略上，

更新日期：2021-04-29

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