细胞外基质的组成和功能指南,The FEBS Journal

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细胞外基质的组成和功能指南
The FEBS Journal ( IF 5.5 ) Pub Date : 2021-02-19 , DOI: 10.1111/febs.15776
Nikos K. Karamanos _{1,

2} , Achilleas D. Theocharis ₁ , Zoi Piperigkou _{1,

2} , Dimitra Manou ₁ , Alberto Passi ₃ , Spyros S. Skandalis ₁ , Demitrios H. Vynios ₁ , Véronique Orian‐Rousseau ₄ , Sylvie Ricard‐Blum ₅ , Christian E.H. Schmelzer _{6,

7} , Laurent Duca ₈ , Madeleine Durbee ₉ , Nikolaos A. Afratis ₁₀ , Linda Troeberg ₁₁ , Marco Franchi ₁₂ , Valentina Masola ₁₃ , Maurizio Onisto ₁₃

Affiliation

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group Laboratory of Biochemistry Department of Chemistry University of Patras 26504 Patras Greece
Foundation for Research and Technology‐Hellas (FORTH)/Institute of Chemical Engineering Sciences (ICE‐HT) Patras 26110 Greece
Department of Medicine and Surgery University of Insubria Varese Italy
Karlsruhe Institute of Technology Institute of Biological and Chemical Systems‐ Functional Molecular Systems Eggenstein‐Leopoldshafen 76344 Germany
University of Lyon, UMR 5246, ICBMS, Université Lyon 1, CNRS 43 Boulevard du 11 novembre 1918 69622 Villeurbanne Cedex France
Fraunhofer Institute for Microstructure of Materials and Systems IMWS Halle (Saale) Germany
Institute of Pharmacy, Faculty of Natural Sciences I Martin Luther University Halle‐Wittenberg Halle (Saale) Germany
UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Team 2: Matrix Aging and Vascular Remodelling Université de Reims Champagne Ardenne (URCA) UFR Sciences Exactes et Naturelles Reims France
Lund University Department of Experimental Medical Science Unit of Muscle Biology BMC C12, 221 84 Lund Sweden
Department Biological Regulation Weizmann Institute of Science 234 Herzl Street Rehovot 7610001 Israel
Norwich Medical School University of East Anglia Bob Champion Research and Education Building Rosalind Franklin Road Norwich NR4 7UQ United Kingdom
Department for Life Quality Study University of Bologna 47921 Rimini Italy
Department of Biomedical Sciences University of Padova 35121 Padova Italy

细胞外基质 (ECM) 是一种动态的 3 维大分子网络，可为细胞和组织提供结构支持。过去十年积累的知识清楚地表明，ECM 起着关键的调节作用，因为它协调细胞信号、功能、特性和形态。细胞外分泌以及细胞结合因子是 ECM 家族的主要成员之一。蛋白质/糖蛋白，例如胶原蛋白、弹性蛋白、层粘连蛋白和生腱蛋白、蛋白聚糖和糖胺聚糖、乙酰透明质酸及其细胞受体，例如负责细胞粘附的 CD44 和整联蛋白，构成一个组织良好的功能网络，在健康和疾病中发挥重要作用。另一方面，基质金属蛋白酶等酶和特定糖苷酶（包括乙酰肝素酶和透明质酸酶）有助于基质重塑并影响人类健康。一些细胞过程和功能，其中细胞增殖和存活、迁移、分化、自噬、血管生成和免疫调节受某些基质成分的影响。结构改变也与疾病进展密切相关。本 ECM 组成和功能指南对基质体、主要 ECM 大分子及其在 ECM 内和与细胞表面的相互作用网络进行了广泛的概述，总结了它们的主要结构特征及其在组织组织和细胞功能中的作用,

"点击查看英文标题和摘要"

A guide to the composition and functions of the extracellular matrix

Extracellular matrix (ECM) is a dynamic 3-dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated knowledge clearly demonstrated over the last decade that ECM plays key regulatory roles since it orchestrates cell signaling, functions, properties and morphology. Extracellularly secreted as well as cell-bound factors are among the major members of the ECM family. Proteins/glycoproteins, such as collagens, elastin, laminins and tenascins, proteoglycans and glycosaminoglycans, hyaluronan, and their cell receptors such as CD44 and integrins, responsible for cell adhesion, comprise a well-organized functional network with significant roles in health and disease. On the other hand, enzymes such as matrix metalloproteinases and specific glycosidases including heparanase and hyaluronidases contribute to matrix remodeling and affect human health. Several cell processes and functions, among them cell proliferation and survival, migration, differentiation, autophagy, angiogenesis, and immunity regulation are affected by certain matrix components. Structural alterations have been also well associated with disease progression. This guide on the composition and functions of the ECM gives a broad overview of the matrisome, the major ECM macromolecules, and their interaction networks within the ECM and with the cell surface, summarizes their main structural features and their roles in tissue organization and cell functions, and emphasizes the importance of specific ECM constituents in disease development and progression as well as the advances in molecular targeting of ECM to design new therapeutic strategies.

更新日期：2021-02-19

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