Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement. Attempts in this area tend to develop new forms to make their applications more convenient and wider. Here, we propose a novel Chinese herb microneedle (CHMN) patch by integrating the herbal extracts, Premna microphylla and Centella asiatica, with microstructure of microneedle for wound healing. Such path is composed of sap extracted from the herbal leaves via traditional kneading method and solidified by plant ash derived from the brine induced process of tofu in a well-designed mold. Because the leaves of the Premna microphylla are rich in pectin and various amino acids, the CHMN could be imparted with medicinal efficacy of heat clearing, detoxicating, detumescence and hemostatic. Besides, with the excellent pharmaceutical activity of Asiatic acid extracted from Centella asiatica, the CHMN is potential in promoting relevant growth factor genes expression in fibroblasts and showing excellent performance in anti-oxidant, anti-inflammatory and anti-bacterial activity. Taking advantages of these pure herbal compositions, we have demonstrated that the derived CHMN was with dramatical achievement in anti-bacteria, inhibiting inflammatory, collagen deposition, angiogenesis and tissue reconstruction during the wound closure. These results indicate that the integration of traditional Chinese herbs with progressive technologies will facilitate the development and promotion of traditional Chinese medicine in modern society.

中医药和中草药对于疾病治疗和亚健康改善具有明显的价值。这方面的尝试往往会开发新的形式，使其应用​​更加方便和广泛。在这里，我们提出了一种新型中草药微针（CHMN）贴片，将草药提取物、小叶柴和积雪草与微针的微观结构相结合，用于伤口愈合。这种路径由通过传统揉捏方法从草药叶子中提取的汁液组成，并通过精心设计的模具中豆腐盐水诱导过程中产生的草木灰进行固化。由于小叶Premna microphylla的叶富含果胶和多种氨基酸，CHMN具有清热、解毒、消肿、止血的药用功效。此外，积雪草中提取的积雪草酸具有优异的药用活性，CHMN有望促进成纤维细胞中相关生长因子基因的表达，并表现出优异的抗氧化、抗炎和抗菌活性。利用这些纯草药组合物，我们证明了衍生的CHMN在抗菌、抑制炎症、胶原蛋白沉积、血管生成和伤口闭合过程中的组织重建方面取得了显着的成就。这些结果表明，中药与先进技术的融合将有利于中医药在现代社会的发展和推广。