Overall Structure Construction of an Intervertebral Disk Based on Highly Anisotropic Wood Hydrogel Composite Materials with Mechanical Matching and Buckling Buffering,ACS Applied Materials & Interfaces

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Overall Structure Construction of an Intervertebral Disk Based on Highly Anisotropic Wood Hydrogel Composite Materials with Mechanical Matching and Buckling Buffering
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-03-23 , DOI: 10.1021/acsami.1c02487
Jinming Liu ₁ , Dingqian Wang ₁ , Yanyan Li ₁ , Ziqi Zhou ₁ , Dongyue Zhang _{1,

2} , Jianshu Li _{1,

2} , Hetao Chu ₁

Affiliation

Natural intervertebral disks (IVDs) exhibit distinctive anisotropic mechanical support and dissipation performances due to their well-developed special microstructures. As the intact IVD structure degrades, the absence of function will lead to severe backache. However, the complete simulation for the characteristic structure and function of native IVD is unattainable using current methods. In this work, by overall construction of the two-phase structure of native IVD (extraction of the naturally aligned cellulose framework and in situ polymerization of the nanocomposite hydrogel), a complete wood framework IVD (WF-IVD) is manufactured containing elastic nanocomposite hydrogel-based nucleus pulposus (NP) and anisotropic wood cellulose hydrogel-based annulus fibrosus (AF). In addition to the imitation and construction of the natural structure, WF-IVD also achieves favorable mechanical matching and good biocompatibility and possesses unique mechanical buckling buffer characteristics owing to the aligned fiber bundles. This study offers a promising strategy for the mimicking and construction of complex native tissues.

中文翻译：

高度各向异性的木质水凝胶复合材料与机械匹配和屈曲缓冲的椎间盘整体结构构建

天然椎间盘（IVD）由于其发达的特殊微结构而具有独特的各向异性机械支撑和耗散性能。随着完整的IVD结构的退化，功能的缺失将导致严重的腰酸。但是，使用当前方法无法对本地IVD的特征结构和功能进行完整的仿真。在这项工作中，通过整体构建天然IVD的两相结构（自然排列的纤维素骨架的提取和纳米复合水凝胶的原位聚合），制造出了完整的包含弹性纳米复合水凝胶的木质骨架IVD（WF-IVD）。基核髓核（NP）和各向异性木质纤维素水凝胶基纤维环（AF）。除了模仿和建造自然结构外，WF-IVD还具有良好的机械匹配性和良好的生物相容性，并且由于排列的纤维束而具有独特的机械屈曲缓冲特性。这项研究为模仿和构建复杂的天然组织提供了一种有前途的策略。

更新日期：2021-04-08

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