Tackling the Selectivity Dilemma of Benzopyrylium–Coumarin Dyes in Fluorescence Sensing of HClO and SO2,Analytical Chemistry

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Tackling the Selectivity Dilemma of Benzopyrylium–Coumarin Dyes in Fluorescence Sensing of HClO and SO2
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-03-19 , DOI: 10.1021/acs.analchem.0c05266
Jinliang Han ₁ , Sheng Yang ₁ , Benhua Wang ₁ , Xiangzhi Song _{1,

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Affiliation

Benzopyrylium–coumarin fluorescent probes for sensing hypochlorous acid (HClO) or sulfur dioxide (SO₂) are unable to distinguish between HClO and SO₂ because the two compounds can react with the 4-position of benzopyrylium–coumarin dyes through the nucleophilic attack. In the current work, we introduced a phenoxazine moiety to the benzopyrylium–coumarin dye to synthesize a new fluorescent probe PBC1, which can dually sense HClO and SO₂ and generate distinct fluorescence signals with rapid response time and high sensitivity and selectivity. Moreover, probe PBC1 was also successfully utilized to detect intracellular HClO and SO₂ in HeLa cells and zebrafish.

中文翻译：

在HClO和SO _2的荧光传感中解决苯并吡啶-香豆素染料的选择性难题

用于检测次氯酸（HClO）或二氧化硫（SO ₂）的苯并吡啶-香豆素荧光探针无法区分HClO和SO _2，因为这两种化合物可通过亲核攻击与苯并吡啶-香豆素染料的4位反应。在当前的工作中，我们在苯并吡啶-香豆素染料中引入了吩恶嗪部分，以合成新的荧光探针PBC1，该探针可以双重感应HClO和SO ₂并以快速的响应时间，高灵敏度和选择性产生独特的荧光信号。此外，探针PBC1还成功地用于检测HeLa细胞和斑马鱼中的细胞内HClO和SO ₂。

更新日期：2021-03-30

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