Ferroptosis: An emerging therapeutic target in stroke,Journal of Neurochemistry

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Ferroptosis: An emerging therapeutic target in stroke
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2021-03-18 , DOI: 10.1111/jnc.15351
Yibo Liu ₁ , Yuanjian Fang ₁ , Zeyu Zhang ₁ , Yujie Luo ₁ , Anke Zhang ₁ , Cameron Lenahan ₂ , Sheng Chen ₁

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Stroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed molecular mechanism of brain injury after stroke, these studies have not yet translated into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically and is characterized by iron-dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently revealed to also be a significant factor in the pathological process of stroke. A better understanding of ferroptosis in stroke may provide us with better therapeutic targets to treat this devastating disease. Here, we systematically summarized the current mechanism of ferroptosis and reviewed the current studies regarding the relationship between ferroptosis and stroke.

中文翻译：

铁死亡：中风的新兴治疗靶点

中风是一种具有高发病率和死亡率的灾难性神经系统疾病。病理过程的机制极其复杂且不清楚。尽管许多基础研究已经证实了脑卒中后脑损伤的分子机制，但这些研究尚未转化为治疗和临床应用。铁死亡是一种细胞死亡形式，在形态和生化上不同于坏死、细胞凋亡和自噬，其特征在于脂质过氧化物的铁依赖性积累。尽管首先在癌细胞中发现了铁死亡，但最近发现它也是中风病理过程中的一个重要因素。更好地了解中风铁死亡可能为我们提供更好的治疗靶点来治疗这种破坏性疾病。这里，

更新日期：2021-03-18

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