Wound Dressing Hydrogel of Enteromorpha prolifera Polysaccharide–Polyacrylamide Composite: A Facile Transformation of Marine Blooming into Biomedical Material,ACS Applied Materials & Interfaces

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Wound Dressing Hydrogel of Enteromorpha prolifera Polysaccharide–Polyacrylamide Composite: A Facile Transformation of Marine Blooming into Biomedical Material
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-03-17 , DOI: 10.1021/acsami.0c21543
Fei Jiang ₁ , Zhe Chi ₁ , Yuanyuan Ding ₁ , Meilin Quan ₁ , Yu Tian ₁ , Jie Shi ₂ , Fulai Song ₂ , Chenguang Liu ₁

Affiliation

Great endeavors have been dedicated to the development of wound dressing materials. However, there is still a demand for developing a wound dressing hydrogel that integrates natural macromolecules without requiring extra chemical modifications, so as to enable a facile transformation and practical application in wound healing. Herein, a composite hydrogel was prepared with water-soluble polysaccharides from Enteromorpha prolifera (PEP) cross-linked with boric acid and polyacrylamide cross-linked via polymerization (PAM) using a one-pot method. The dual-network of this hydrogel enabled it to have an ultratough mechanical strength. Moreover, interfacial characterizations reflected that the hydrogen bonds and dynamic hydroxyl–borate bonds contributed to the self-healing ability of the PEP-PAM hydrogel, and the surface groups on the hydrogel allowed for tissue adhesiveness and natural antioxidant properties. Additionally, human epidermal growth factor-loaded PEP-PAM hydrogel promoted cell proliferation and migration in vitro and significantly accelerated wound healing in vivo on model rats. These progresses suggested a prospect for the PEP-PAM hydrogel as an effective and easily available wound dressing material. Remarkably, this work showcases that a wound dressing hydrogel can be facially developed by using natural polysaccharides as a one component and offers a new route for the high-value utilization of disastrous marine blooming biomass by transforming it into a biomedical material.

中文翻译：

Enter肠多糖-聚丙烯酰胺复合物伤口敷料水凝胶：海洋开花向生物医学材料的便捷转化

致力于伤口敷料材料的巨大努力。但是，仍然需要开发一种伤口敷料水凝胶，其不需要任何额外的化学修饰就可以整合天然大分子，从而能够轻松转化并在伤口愈合中得到实际应用。在此，使用来自肠Enter的水溶性多糖制备了复合水凝胶。通过一锅法通过聚合（PAM）与硼酸（聚丙烯酸酯）交联的聚丙烯酸酯（PEP）和聚丙烯酰胺。这种水凝胶的双重网络使其具有超强的机械强度。此外，界面特征反映出氢键和动态羟基硼酸酯键有助于PEP-PAM水凝胶的自愈能力，并且水凝胶上的表面基团具有组织粘合性和天然抗氧化特性。此外，载有人表皮生长因子的PEP-PAM水凝胶可促进体外细胞增殖和迁移，并显着加速模型大鼠的体内伤口愈合。这些进展表明，PEP-PAM水凝胶有望成为一种有效且易于获得的伤口敷料。值得注意的是

更新日期：2021-03-31

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