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Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2021-03-18 , DOI: 10.1016/j.biopha.2021.111511
Shahid Ali Rajput 1 , Xiu-Qi Wang 1 , Hui-Chao Yan 1
Affiliation  

Flavonoids are natural plant-derived dietary bioactive compounds having a substantial impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem, and leaves of Moraceae family members' plants. Plenty of evidences supported that morin hydrate exerts its beneficial effects against various chronic and life-threatening degenerative diseases. Our current article discloses the recent advances that have been studied to explore the biological/pharmacological properties and molecular mechanisms to better understand the beneficial and multiple health benefits of morin hydrate. Indeed, Morin hydrate exerts free radical scavenging, antioxidant, anti-inflammatory, anti-cancerous, anti-microbial, antidiabetic, anti-arthritis, cardioprotective, neuroprotective, nephroprotective, and hepatoprotective effects. Moreover, morin hydrate exhibits its pharmacological activities by modulating various cellular signaling pathways such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-қB), Mitogen-activated protein kinase (MAPK), Janus kinases/ Signal transducer and activator of transcription proteins (JAKs/STATs), Kelch-like ECH-associated protein1/Nuclear erythroid-2-related factor (Keap1/Nrf2), Endoplasmic reticulum (ER), Mitochondrial-mediated apoptosis, Wnt/β-catenin, and Mechanistic target of rapamycin (mTOR). Most importantly, morin hydrate has the potential to modulate a variety of biological networks. Therefore, it can be predicted that this therapeutically potent compound could serve as a dietary agent for the expansion of human health and might be helpful for the development of the novel drug in the future. However, due to the lack of clinical trials, special human clinical trials are needed to address the effects of morin hydrate on various life-threatening disparities to recommend morin and/or morin-rich foods with other foods or bioactive dietary components, as well as dose-response interaction and safety profile.



中文翻译:

莫林水合物:具有多种生物和药理潜力的新型天然膳食生物活性化合物的全面综述

类黄酮是天然植物来源的饮食生物活性化合物,对人体健康具有重大影响。桑色素水合物是一种生物类黄酮,主要从桑科植物的果实,茎和叶中获得。大量证据支持水合茉莉酸对多种慢性和危及生命的退行性疾病发挥有益作用。我们当前的文章披露了已研究的最新进展,以探索生物学/药理学性质和分子机制,以更好地了解水合茉莉香精的有益健康和多重健康益处。实际上,莫林水合物具有清除自由基,抗氧化剂,抗炎,抗癌,抗微生物,抗糖尿病,抗关节炎,心脏保护,神经保护,肾保护和肝保护作用。而且,水合莫林水合物通过调节各种细胞信号通路,例如活化B细胞的核因子κ-轻链增强子(NF-қB),丝裂原活化蛋白激酶(MAPK),Janus激酶/信号转导子和活化剂,展现其药理活性。转录蛋白(JAKs / STATs),类似Kelch的ECH相关蛋白1 /核红系2相关因子(Keap1 / Nrf2),内质网(ER),线粒体介导的细胞凋亡,Wnt /β-catenin和机制靶标雷帕霉素(mTOR)。最重要的是,水合莫林具有调节多种生物网络的潜力。因此,可以预见,这种治疗有效的化合物可以用作促进人类健康的饮食剂,并且可能在将来开发新药。然而,

更新日期:2021-03-18
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