Abstract Three photoactive chitosan derivatives were synthesized using TBDMS chitosan as the starting material. In this study, we also report an optimized method for producing relatively high average molecular weight chitosan precursors for the synthesis of the three N-modified chitosan derivatives having a N-azidobenzoyl group, a N-methacryloyl group and a N-azidobenzoyl-N′,N′,N′-(acetyl-trimethyl ammoniumyl) group. The methacryloyl and azidobenzoyl derivatives synthesized were photografted onto discs of a crosslinked polymethacrylate copolymer used in the industrial production of intraocular lenses (IOLs), with dimensions comparable to those of IOLs. The photografted polymethacrylate was loaded with the antibiotic moxifloxacin, allowing the creation of an antibiotic releasing system that may be further developed for an application in postoperative endophthalmitis prophylaxis.

中文翻译：

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TBDMS壳聚糖在光活性壳聚糖衍生物合成中的应用及在眼镜片材料的光接枝中的应用

摘要以TBDMS壳聚糖为起始原料，合成了三种光活性壳聚糖衍生物。在这项研究中，我们还报告了一种生产相对较高平均分子量的壳聚糖前体的优化方法，该方法用于合成具有N-叠氮基苯甲酰基，N-甲基丙烯酰基和N-叠氮基苯甲酰基-N'的三种N-改性的壳聚糖衍生物。 ，N′，N′-（乙酰基三甲基铵基）基团。将合成的甲基丙烯酰基和叠氮苯甲酰基衍生物光接枝到用于人工晶状体（IOL）工业生产中的交联聚甲基丙烯酸酯共聚物的圆盘上，其尺寸可与IOL的尺寸相比。在光接枝的聚甲基丙烯酸酯上装载了莫西沙星抗生素，