Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Alkyl Bromides: Et3N as the Terminal Reductant,Organic Letters

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Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Alkyl Bromides: Et3N as the Terminal Reductant
Organic Letters ( IF 4.9 ) Pub Date : 2016-07-29 00:00:00 , DOI: 10.1021/acs.orglett.6b01837
Zhengli Duan ₁ , Wu Li ₁ , Aiwen Lei ₁

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Reductive cross-coupling has emerged as a direct method for the construction of carbon–carbon bonds. Most cobalt-, nickel-, and palladium-catalyzed reductive cross-coupling reactions to date are limited to stoichiometric Mn(0) or Zn(0) as the reductant. One nickel-catalyzed cross-coupling paradigm using Et₃N as the terminal reductant is reported. By using this photoredox catalysis and nickel catalysis approach, a direct Csp²–Csp³ reductive cross-coupling of aryl bromides with alkyl bromides is achieved under mild conditions without stoichiometric metal reductants.

中文翻译：

镍催化的芳基溴化物与烷基溴化物的交叉还原偶联反应：Et ₃ N作为末端还原剂

还原性交叉偶联已经成为构建碳-碳键的直接方法。迄今为止，大多数钴，镍和钯催化的还原性交叉偶联反应仅限于化学计量的Mn（0）或Zn（0）作为还原剂。报道了一种使用Et ₃ N作为末端还原剂的镍催化交叉偶联范例。通过使用这种光氧化还原催化和镍催化方法，在温和条件下无需化学计量的金属还原剂即可实现芳基溴化物与烷基溴化物的直接Csp ² -Csp ³还原交叉偶联。

更新日期：2016-07-29

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